Technology Process of 3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione
There total 7 articles about 3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-indolylacetamide; methyl 2-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-2-oxoacetate;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
With
hydrogenchloride;
In
tetrahydrofuran;
at 20 ℃;
Further stages.;
DOI:10.1021/jo001605g
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 1 h / 20 °C
1.2: 96 percent / dimethylformamide / 16 h / 20 °C
2.1: 91 percent / 1 N HCl / tetrahydrofuran / 20 °C
3.1: 82 percent / Bu2SnO; CsF / dimethylformamide / 4 h / 20 °C
4.1: NaH / tetrahydrofuran / 1 h / 45 °C
4.2: 58 percent / tetrahydrofuran / 18 h / 45 °C
5.1: 97 percent / LiBH4 / tetrahydrofuran; ethanol / 0 - 20 °C
6.1: diethyl ether / 0.5 h / 0 °C
6.2: 91 percent / diethyl ether; methanol / -60 - 20 °C
7.1: t-BuOK / tetrahydrofuran / 6 h / 20 °C
7.2: 74 percent / conc. HCl / tetrahydrofuran / 20 °C
With
hydrogenchloride; lithium borohydride; potassium tert-butylate; sodium hydride; di(n-butyl)tin oxide; cesium fluoride;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo001605g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 82 percent / Bu2SnO; CsF / dimethylformamide / 4 h / 20 °C
2.1: NaH / tetrahydrofuran / 1 h / 45 °C
2.2: 58 percent / tetrahydrofuran / 18 h / 45 °C
3.1: 97 percent / LiBH4 / tetrahydrofuran; ethanol / 0 - 20 °C
4.1: diethyl ether / 0.5 h / 0 °C
4.2: 91 percent / diethyl ether; methanol / -60 - 20 °C
5.1: t-BuOK / tetrahydrofuran / 6 h / 20 °C
5.2: 74 percent / conc. HCl / tetrahydrofuran / 20 °C
With
lithium borohydride; potassium tert-butylate; sodium hydride; di(n-butyl)tin oxide; cesium fluoride;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo001605g