C₃₉H₅₄N₁₂O₉

Base Information

• Chemical Name: C₃₉H₅₄N₁₂O₉
• CAS No.: 1364254-00-1
• Molecular Formula: C₃₉H₅₄N₁₂O₉
• Molecular Weight: 834.933
• Mol file: 1364254-00-1.mol

Synonyms:C₃₉H₅₄N₁₂O₉

Chemical Property of C₃₉H₅₄N₁₂O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₅₄N₁₂O₉

There total 3 articles about C₃₉H₅₄N₁₂O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

C29H37N11O4 (1364253-98-4) + tert-butyl (2-(2-((((2,5-dioxopyrrolidin-1-yl)oxy)carbonyl)oxy)ethoxy)ethyl)carbamate (261364-63-0) → C39H54N12O9 (1364254-00-1)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 19h;

DOI:10.1021/ja2108855

Reference yield:

(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid (79640-70-3) → C39H54N12O9 (1364254-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: pyridine / N,N-dimethyl-formamide / 19 h / 20 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja2108855

Reference yield:

histamine dihydrochloride (55-36-7,56-92-8,23758-34-1,78654-37-2) → C39H54N12O9 (1364254-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: pyridine / N,N-dimethyl-formamide / 19 h / 20 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja2108855

upstream raw materials:

C₂₉H₃₇N₁₁O₄

tert-butyl (2-(2-((((2,5-dioxopyrrolidin-1-yl)oxy)carbonyl)oxy)ethoxy)ethyl)carbamate

histamine dihydrochloride

(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid

Refernces