4-chloromandelonitrile

Base Information

• Chemical Name: 4-chloromandelonitrile
• CAS No.: 13312-83-9
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.595
• Mol file: 13312-83-9.mol

Synonyms:4-chloromandelonitrile

Chemical Property of 4-chloromandelonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloromandelonitrile

There total 61 articles about 4-chloromandelonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + 4-chlorobenzaldehyde (104-88-1) → 4-chloromandelonitrile (13312-83-9)

Guidance literature:

With P(i-PrNCH₂CH₂)N; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2005.09.032

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + 4-chlorobenzaldehyde (104-88-1) → (R)-(+)-4-chloromandelonitrile (13312-83-9,96523-99-8,106863-47-2,97070-79-6)

Guidance literature:

With 4 A molecular sieve; dimethylaluminum chloride; Triphenylphosphine oxide; (S)-3,3'-bis[(diethylamino)methyl]-2,2'-dihydroxy-1,1'-binaphthalene; In toluene; at -20 ℃; for 21h;

DOI:10.1021/ol0262338

Reference yield: 98.0%

hydrogen cyanide (74-90-8) + 4-chlorobenzaldehyde (104-88-1) → (R)-(+)-4-chloromandelonitrile (13312-83-9,96523-99-8,106863-47-2,97070-79-6)

Guidance literature:

With (R)-hydroxynitrile lyase from Prunus amygdalus; In di-isopropyl ether; at 0 ℃; for 24.5h;

upstream raw materials:

hydrogen cyanide

4-chlorobenzaldehyde

potassium cyanide

benzoyl cyanide

Downstream raw materials:

4-chloro-mandelimidic acid ethyl ester; hydrochloride

2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone

p-chloromandelic acid

p-chlorophenyl-α-chloroacetic acid

Refernces

• 1、 Overberger,Chien. "-". . p. 5874. Retrieved 1960.
• 2、 Juhl, Martin,Petersen, Allan R.,Lee, Ji-Woong. "CO2-Enabled Cyanohydrin Synthesis and Facile Iterative Homologation Reactions**". supporting information. p. 228 - 232. Retrieved 2020/11/30.