N-ACETYL-3-(2,5-DIFLUOROPHENYL)-D-ALANINE

Base Information

• Chemical Name: N-ACETYL-3-(2,5-DIFLUOROPHENYL)-D-ALANINE
• CAS No.: 266360-55-8
• Molecular Formula: C11H11F2NO3
• Molecular Weight: 243.21
• Hs Code.: 2924299090
• Mol file: 266360-55-8.mol

Synonyms:N-acetyl-3-(2,5-difluorophenyl)-D-alanine;

Chemical Property of N-ACETYL-3-(2,5-DIFLUOROPHENYL)-D-ALANINE

Chemical Property:

• Vapor Pressure: 8.11E-09mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 448.186 °C at 760 mmHg
• PKA: 3.48±0.12(Predicted)
• Flash Point: 224.855 °C
• PSA: 66.40000
• Density: 1.343 g/cm³
• LogP: 1.48750
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-Acetamido-3-(2,5-difluorophenyl)-propanoic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ACETYL-3-(2,5-DIFLUOROPHENYL)-D-ALANINE

There total 4 articles about N-ACETYL-3-(2,5-DIFLUOROPHENYL)-D-ALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylamino-3-(2,5-difluoro-phenyl)-propionic acid (266360-49-0) → (S)-2-Amino-3-(2,5-difluoro-phenyl)-propionic acid (31105-92-7,266360-61-6) + (R)-2-Acetylamino-3-(2,5-difluoro-phenyl)-propionic acid (266360-55-8)

Guidance literature:

With sodium hydroxide; Aspergillus genus acylase; sodium acetate; In water; at 38 ℃; for 48h; pH=8.0;

DOI:10.1016/S0040-4039(99)02191-7

Reference yield:

Diethyl-α-(2,5-difluorobenzyl)-α-acetamidomalonate (64134-17-4) → (R)-2-Acetylamino-3-(2,5-difluoro-phenyl)-propionic acid (266360-55-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 2M NaOH / methanol; H₂O / 3 h / 40 °C

2: 92 percent / p-xylene / 2 h / Heating

3: Aspergillus genus acylase; 0.2 M AcONa; 0.2 M NaOH / H₂O / 48 h / 38 °C / pH 8.0

With sodium hydroxide; Aspergillus genus acylase; sodium acetate; In methanol; para-xylene; water; 1: Hydrolysis / 2: Decarboxylation / 3: Deacetylation;

DOI:10.1016/S0040-4039(99)02191-7

Reference yield:

2-(bromomethyl)-1,4-difluorobenzene (85117-99-3) → (R)-2-Acetylamino-3-(2,5-difluoro-phenyl)-propionic acid (266360-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / NaOEt / ethanol / 2 h / Heating

2: 2M NaOH / methanol; H₂O / 3 h / 40 °C

3: 92 percent / p-xylene / 2 h / Heating

4: Aspergillus genus acylase; 0.2 M AcONa; 0.2 M NaOH / H₂O / 48 h / 38 °C / pH 8.0

With sodium hydroxide; Aspergillus genus acylase; sodium ethanolate; sodium acetate; In methanol; ethanol; para-xylene; water; 1: Alkylation / 2: Hydrolysis / 3: Decarboxylation / 4: Deacetylation;

DOI:10.1016/S0040-4039(99)02191-7

upstream raw materials:

2-acetylamino-3-(2,5-difluoro-phenyl)-propionic acid

Diethyl-α-(2,5-difluorobenzyl)-α-acetamidomalonate

2-(bromomethyl)-1,4-difluorobenzene

Downstream raw materials:

(R)-2-Amino-3-(2,5-difluoro-phenyl)-propionic acid

Refernces