3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester

Base Information

• Chemical Name: 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester
• CAS No.: 1208318-04-0
• Molecular Formula: C₂₃H₂₃IN₂O₃
• Molecular Weight: 502.352
• Mol file: 1208318-04-0.mol

Synonyms:3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester

Chemical Property of 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester

There total 1 articles about 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester (1208318-04-0)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 16h; Reflux;

Reference yield: 93.0%

imidazolidone (120-93-4) + 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester (1208318-04-0) → 3-[1-(4-carbamoyl-2-methylphenyl)-5-[4-(2-oxo-imidazolidin-1-yl)phenyl]-1H-pyrrol-2-yl]propionic acid ethyl ester (1208318-17-5)

Guidance literature:

imidazolidone; 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester; With potassium phosphate; copper(l) iodide; N,N-dimethylethylenediamine; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

imidazolidone; With copper(l) iodide; In N,N-dimethyl-formamide; at 130 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.07.103

Reference yield: 53.0%

morpholine (110-91-8,99108-56-2) + 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-iodophenyl)-1H-pyrrol-2-yl]propanoic acid ethyl ester (1208318-04-0) → 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-morpholin-4-yl-phenyl-1H-pyrrole-2-yl)]propionic acid ethyl ester (1208318-20-0)

Guidance literature:

With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmcl.2011.07.103

Downstream raw materials:

3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-morpholin-4-yl-phenyl-1H-pyrrole-2-yl)]propionic acid ethyl ester

3-[1-(4-carbamoyl-2-methylphenyl)-5-[4-(2-oxo-imidazolidin-1-yl)phenyl]-1H-pyrrol-2-yl]propionic acid ethyl ester

3-(1-(4-(1H-pyrazol-4-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid ethyl ester

3-[1-(4-carbamoyl-2-methylphenyl)-5-[4-(2-oxo-imidazolidin-1-yl)phenyl]-1H-pyrrol-2-yl]propionic acid

Refernces