Technology Process of (E)-3-(3-chloro-6-cyano-2-fluorophenyl)acrylic acid
There total 6 articles about (E)-3-(3-chloro-6-cyano-2-fluorophenyl)acrylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; lithium hydroxide;
In
tetrahydrofuran;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide; trichlorophosphate / 2 h / 110 °C
2: palladium diacetate; sodium hydrogencarbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 22 h / 20 - 90 °C
3: lithium hydroxide; methanol / tetrahydrofuran / 2 h
With
methanol; tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate; sodium hydroxide; lithium hydroxide; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / dichloromethane / 3 h / Reflux
2: ammonia / 0.5 h / 0 °C
3: sodium hydroxide; trichlorophosphate / 2 h / 110 °C
4: palladium diacetate; sodium hydrogencarbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 22 h / 20 - 90 °C
5: lithium hydroxide; methanol / tetrahydrofuran / 2 h
With
methanol; thionyl chloride; tetrabutylammomium bromide; ammonia; palladium diacetate; sodium hydrogencarbonate; sodium hydroxide; lithium hydroxide; trichlorophosphate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;