Technology Process of diethyl N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7-(3',4'-dimethoxybenzyl)pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate
There total 13 articles about diethyl N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7-(3',4'-dimethoxybenzyl)pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate;
In
N,N-dimethyl-formamide;
DOI:10.1021/jo001580l
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 95 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C
2.1: 90 percent / KOH; N2H4*H2O / ethane-1,2-diol / 110 °C
3.1: 87 percent / Et3N; DMAP / ethyl acetate / 0 - 20 °C
4.1: 86 percent / Mn(OAc)3*2H2O; Cu(OAc)2*H2O / acetic acid / 20 °C
5.1: 85 percent / P4S10 / tetrahydrofuran / Heating
6.1: NaOMe / methanol / 0.5 h / 20 °C
6.2: 68 percent / methanol / 1 h / 90 °C / 15 Torr
7.1: 65 percent / Et3N; CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide
With
dmap; potassium hydroxide; copper(l) iodide; tetraphosphorus decasulfide; copper diacetate; sodium methylate; manganese triacetate; tetra-(n-butyl)ammonium iodide; sodium hydride; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate;
In
tetrahydrofuran; methanol; ethylene glycol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
7.1: Heck reaction;
DOI:10.1021/jo001580l
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaOMe / methanol / 0.5 h / 20 °C
1.2: 68 percent / methanol / 1 h / 90 °C / 15 Torr
2.1: 65 percent / Et3N; CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide
With
copper(l) iodide; sodium methylate; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate;
In
methanol; N,N-dimethyl-formamide;
2.1: Heck reaction;
DOI:10.1021/jo001580l