Furan-2-yl(phenyl)methanol

Base Information

• Chemical Name: Furan-2-yl(phenyl)methanol
• CAS No.: 4484-57-5
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.199
• Hs Code.: 2932190090
• European Community (EC) Number: 844-794-4
• DSSTox Substance ID: DTXSID30395855
• Nikkaji Number: J636.104H
• Mol file: 4484-57-5.mol

Synonyms:furan-2-yl(phenyl)methanol;2-Furyl(phenyl)methanol;4484-57-5;2-furyl(phenyl)carbinol;EC-000.1530;1-furyl-1-phenyl-methanol;alpha-Phenyl-2-furanmethanol;SCHEMBL477450;(furan-2-yl)(phenyl)methanol;2-furanmethanol, alpha-phenyl-;DTXSID30395855;FWIQIDYJWKRMFG-UHFFFAOYSA-N;(+/-) 2-alpha-hydroxybenzylfuran;(+/-) 2-(alpha-hydroxybenzyl)furan;AKOS000249692;AKOS022300322;CS-0249545;FT-0691689;EN300-43843

Chemical Property of Furan-2-yl(phenyl)methanol

Chemical Property:

• Vapor Pressure: 0.00461mmHg at 25°C
• Boiling Point: 265.3°Cat760mmHg
• Flash Point: 114.3°C
• PSA: 33.37000
• Density: 1.162g/cm³
• LogP: 2.36130
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 174.068079557
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

99%min ^*data from raw suppliers

furan-2-yl(phenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CO2)O

Technology Process of Furan-2-yl(phenyl)methanol

There total 38 articles about Furan-2-yl(phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

furan (110-00-9) + benzaldehyde (100-52-7) → 2-furyl(phenyl)methanol (60907-91-7,113565-51-8,132435-41-7,4484-57-5)

Guidance literature:

furan; With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 2h;

benzaldehyde; In tetrahydrofuran; hexane; at 23 ℃; for 16h;

DOI:10.1021/ja029125p

Reference yield: 99.0%

furfural (98-01-1) + bromobenzene (108-86-1,52753-63-6) → 2-furyl(phenyl)methanol (60907-91-7,113565-51-8,132435-41-7,4484-57-5)

Guidance literature:

With iodine; magnesium; In tetrahydrofuran; 1.) reflux; 2.) 20 deg C then 22 deg C;

DOI:10.1016/0040-4020(95)00659-V

Reference yield: 96.0%

furfural (98-01-1) + potassium phenyltrifluoborate → 2-furyl(phenyl)methanol (60907-91-7,113565-51-8,132435-41-7,4484-57-5)

Guidance literature:

With tri-tert-butyl phosphine; chlorobis(ethylene)rhodium(I) dimer; In water; toluene; at 60 ℃;

DOI:10.1039/b506245d

upstream raw materials:

furfural

furan

benzaldehyde

bromobenzene

Downstream raw materials:

2-benzylfuran

6-hydroxy-2-phenyl-2H-pyran-3(6H)-one

2-Furyl(methoxy)phenylmethan

1-phenyl-4,5,5-trimethoxy-pentan-2-one

Refernces

• 1、 Talybov, G. M.. "Isomerization of Propargyl Ethers of 2-Hydroxyoxiranes to Furan Derivatives on Silver Catalysts". . p. 1153 - 1156. Retrieved 2021/08/06.
• 2、 Zhao, Changgui,Wang, Jian. "Divergent Synthesis of Dihydropyranone Stereoisomers via N-Heterocyclic Carbene Catalysis". supporting information. p. 1668 - 1672. Retrieved 2019/02/19.