2,3,4,5-Tetrafluoropyridine

Base Information

• Chemical Name: 2,3,4,5-Tetrafluoropyridine
• CAS No.: 3512-16-1
• Molecular Formula: C5H F4 N
• Molecular Weight: 151.063
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50462518
• Nikkaji Number: J1.101.091A
• Wikidata: Q82287062
• Mol file: 3512-16-1.mol

Synonyms:2,3,4,5-tetrafluoropyridine;3512-16-1;tetrafluoropyridine;SCHEMBL640064;DTXSID50462518;MVRNAPZMQQYTIN-UHFFFAOYSA-N;AKOS006277005;SB53722;FT-0657658

Chemical Property of 2,3,4,5-Tetrafluoropyridine

Chemical Property:

• Vapor Pressure: 45.4mmHg at 25°C
• Refractive Index: 1.403
• Boiling Point: 98.7°Cat760mmHg
• Flash Point: 13.5°C
• PSA: 12.89000
• Density: 1.518g/cm³
• LogP: 1.63800
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 151.00451168
• Heavy Atom Count: 10
• Complexity: 120

Purity/Quality:

98%min ^*data from raw suppliers

2,3,4,5-TETRAFLUOROPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(C(=N1)F)F)F)F

Technology Process of 2,3,4,5-Tetrafluoropyridine

There total 4 articles about 2,3,4,5-Tetrafluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.9%

pyridine (110-86-1) → perfluoro-N-ethylpyrrolidine (2344-10-7) + 2,3,4,5-tetrafluoropyridine (3512-16-1) + Pentafluoropyridine (700-16-3) + N,N-Bis(trifluoromethyl)amine (371-77-7)

Guidance literature:

With caesium tetrafluorocobaltate(III); In gaseous matrix; at 395 - 405 ℃; for 0.5h; Further byproducts given;

DOI:10.1016/S0022-1139(00)81239-7

Reference yield: 35.3%

pyridine (110-86-1) → perfluoro-N-ethylpyrrolidine (2344-10-7) + 2,3,6-trifluoropyridine (3512-18-3) + 2,3,4,5-tetrafluoropyridine (3512-16-1) + Pentafluoropyridine (700-16-3) + N,N-Bis(trifluoromethyl)amine (371-77-7) + tetrafluoro-3-(fluoromethyl)pyridine

Guidance literature:

With caesium tetrafluorocobaltate(III); In gaseous matrix; at 310 ℃; for 3.5h; Product distribution; other reactor geometry, temperature, time;

DOI:10.1016/S0022-1139(00)81239-7

Reference yield:

Pentafluoropyridine (700-16-3) → 3,4-difluoropyridine (82878-63-5) + 3,4,5-trifluoropyridine (67815-54-7) + 2,3,4,5-tetrafluoropyridine (3512-16-1) + 2,3,5,6-tetrafluoropyridine (2875-18-5) + 2,3,5‐trifluoropyridine (76469-41-5)

Guidance literature:

With triethylsilane; α,α,α-trifluorotoluene; C₆₄H₆₈N₂OP₂Ru; In tetrahydrofuran; at 69.84 ℃; for 28h; Time; stereoselective reaction; Schlenk technique; Glovebox;

DOI:10.1021/cs501644r

upstream raw materials:

pyridine

1-fluoromethyl-octafluoropyrrolidine

Pentafluoropyridine

Refernces

• 1、 Plevey, Raymond G.,Rendell, Richard W.,Tatlow, John Colin. "FLUORINATIONS WITH COMPLEX METAL FLUORIDES. PART 6. FLUORINATION OF PYRIDINE AND RELATED COMPOUNDS WITH CAESIUM TETRAFLUOROCOBALTATE(III)". . p. 159 - 170. Retrieved 2007/10/02.