pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide

Base Information

• Chemical Name: pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide
• CAS No.: 124800-67-5
• Molecular Formula: C₂₄H₃₄O₅
• Molecular Weight: 402.531
• Mol file: 124800-67-5.mol

Synonyms:pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide

Chemical Property of pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide

There total 7 articles about pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

pregn-4-ene-9α,16α,17α-triol-3,20-dione (146097-21-4) + acetone (67-64-1) → pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide (124800-67-5)

Guidance literature:

With perchloric acid; at 20 ℃; for 2h;

DOI:10.1007/BF00864351

Reference yield: 70.0%

16α,17α-<1'-isopropylidenedioxy>pregn-4-ene-3,20-dione (4968-09-6) → pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide (124800-67-5)

Guidance literature:

With disodium hydrogenphosphate; potassium dihydrogenphosphate; D-glucose; corn-steep liquor; In water; N,N-dimethyl-formamide; at 28 ℃; for 15h; Rhodococcus sp.;

DOI:10.1016/0039-128X(89)90002-0

Reference yield: 10.0%

3β,-hydroxy-16α,17α-isopropylidenedioxy-5α-pregn-20-one (26302-61-4) → 16α,17α-<1'-isopropylidenedioxy>pregn-4-ene-3,20-dione (4968-09-6) + pregn-4-ene-9α,16α,17α-triol-3,20-dione 16,17-acetonide (124800-67-5)

Guidance literature:

In water; dimethyl sulfoxide; at 28 ℃; for 24h; Rhodococcus sp. culture, maize extract, K₂HPO₄, NaH₂PO₄*12H₂O;

DOI:10.1007/BF00766462

upstream raw materials:

3β,-hydroxy-16α,17α-isopropylidenedioxy-5α-pregn-20-one

16α,17α-<1'-isopropylidenedioxy>pregn-4-ene-3,20-dione

pregn-4-ene-9α,16α,17α-triol-3,20-dione

acetone

Refernces

• 1、 Turuta, A. M.,Voishvillo, N. E.,Kamernitskii, A. V.,Dzhlantiashvili, N. V.,Korobov, A. A.. "TRANSFORMATION OF 5α-H-PREGN-16-EN-3β-OL-20-ONE INTO PREGN-4-ENE-9α,16α,17α-TRIOL-3,20-DIONE 16,17-ACETONIDE". . p. 1482 - 1484. Retrieved 2007/10/02.