Pyrimidine, 2-[(1E)-2-phenylethenyl]- (9CI)

Base Information

• Chemical Name: Pyrimidine, 2-[(1E)-2-phenylethenyl]- (9CI)
• CAS No.: 35782-30-0
• Molecular Formula: C12H10 N2
• Molecular Weight: 182.225
• Hs Code.: 2933599090
• Mol file: 35782-30-0.mol

Synonyms:Pyrimidine,2-(2-phenylethenyl)-, (E)-

Chemical Property of Pyrimidine, 2-[(1E)-2-phenylethenyl]- (9CI)

Chemical Property:

• PSA: 25.78000
• LogP: 2.64700

Purity/Quality:

2-[(1E)-2-PHENYLETHENYL]PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2-[(1E)-2-phenylethenyl]- (9CI)

There total 9 articles about Pyrimidine, 2-[(1E)-2-phenylethenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-methylpyrimidine (5053-43-0) + benzyl alcohol (100-51-6,185532-71-2) → 2-(β-styryl)pyrimidine (35782-30-0)

Guidance literature:

With potassium hydroxide; In toluene; at 120 ℃; for 18h; Sealed tube;

Reference yield: 80.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + trans-2-phenylvinylboronic acid (6783-05-7) → 2-(β-styryl)pyrimidine (35782-30-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In tetrahydrofuran; for 24h; Heating;

DOI:10.1081/SCC-200032495

Reference yield: 71.0%

2-phenethylpyrimidine (1305318-31-3) → 2-(β-styryl)pyrimidine (35782-30-0)

Guidance literature:

With 2-bromo-5-methyl thiophene; nickel(II) bromide dimethoxyethane; bis(2,2,6,6-tetramethyl-1-piperidyl)zinc; tetra-(n-butyl)ammonium iodide; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; toluene; at 85 ℃; for 4h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jacs.9b12706

upstream raw materials:

2-methylpyrimidine

benzaldehyde

bromostyrene

2-(tributylstannyl)pyrimidine

Downstream raw materials:

pyrimidine-2-carboxylic acid

Refernces

• 1、 -. "Method for alkenylation of methyl heterocyclic compound". Paragraph 0111-0114. . Retrieved 2021/02/10.
• 2、 Liu, Jiandong,Ren, Qinghua,Zhang, Xinghua,Gong, Hegui. "Preparation of Vinyl Arenes by Nickel-Catalyzed Reductive Coupling of Aryl Halides with Vinyl Bromides". supporting information. p. 15544 - 15548. Retrieved 2016/12/09.