3-hydroxy-3-phenylcyclobutanone

Base Information

• Chemical Name: 3-hydroxy-3-phenylcyclobutanone
• CAS No.: 1080636-59-4
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.188
• Mol file: 1080636-59-4.mol

Synonyms:3-hydroxy-3-phenylcyclobutanone

Chemical Property of 3-hydroxy-3-phenylcyclobutanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-hydroxy-3-phenylcyclobutanone

There total 2 articles about 3-hydroxy-3-phenylcyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H12O2 (1080636-61-8) → 3-hydroxy-3-phenylcyclobutanone (1080636-59-4)

Guidance literature:

With PS-IBX; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

C17H18O2 (1080636-60-7) → 3-hydroxy-3-phenylcyclobutanone (1080636-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / palladium / methanol / 20 °C

2: PS-IBX / dichloromethane / 4 h / 20 °C

With formic acid; palladium; In methanol; dichloromethane;

Reference yield:

3-hydroxy-3-phenylcyclobutanone (1080636-59-4) + (3R,4R)-4-[3-hydroxy-3-(6-methoxy-quinolin-4-yl)-propyl]-piperidine-3-carboxylic acid (1080636-68-5) → (3R,4R)-4-[3-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-(3-hydroxy-3-phenylcyclobutyl)piperidine-3-carboxylic acid (1082340-67-7)

Guidance literature:

3-hydroxy-3-phenylcyclobutanone; (3R,4R)-4-[3-hydroxy-3-(6-methoxy-quinolin-4-yl)-propyl]-piperidine-3-carboxylic acid; In methanol; at 20 ℃; for 1.25h;

With MP-cyanoborohydride resin; In methanol; at 20 ℃; for 72h;

upstream raw materials:

C₁₀H₁₂O₂

C₁₇H₁₈O₂

Downstream raw materials:

(3R,4R)-4-[3-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-(3-hydroxy-3-phenylcyclobutyl)piperidine-3-carboxylic acid

Refernces