2-AMINO-2-PHENYLPROPIONIC ACID

Base Information

• Chemical Name: 2-AMINO-2-PHENYLPROPIONIC ACID
• CAS No.: 565-07-1
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol file: 565-07-1.mol

Synonyms:Alanine,2-phenyl- (6CI,7CI,8CI);(?à)-a-Phenyl-a-alanine;2-Amino-2-phenylpropanoic acid;DL-a-Methyl-a-phenylglycine;DL-a-Phenylalanine;NSC 16591;a-Amino-a-phenylpropionic acid;

Chemical Property of 2-AMINO-2-PHENYLPROPIONIC ACID

Chemical Property:

• Vapor Pressure: 0.000567mmHg at 25°C
• Melting Point: 295℃
• Refractive Index: 1.567
• Boiling Point: 298.5 °C at 760 mmHg
• PKA: 1.99±0.10(Predicted)
• Flash Point: 134.3 °C
• PSA: 63.32000
• Density: 1.197g/cm³
• LogP: 1.64540
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

DL-2-Phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-2-PHENYLPROPIONIC ACID

There total 30 articles about 2-AMINO-2-PHENYLPROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2'-nitrobenzene)sulfonylamino-2-phenylpropionic acid → 2-amino-2-phenylpropanoic acid (565-07-1,6945-32-0)

Guidance literature:

With sodium methylate; In 1,4-dioxane; methanol; at 20 ℃; for 18h;

DOI:10.1002/ejoc.200600587

Reference yield: 88.0%

2-phenyl-2-(4'-toluenesulfonylamino)propionic acid methyl ester (909731-90-4) → 2-amino-2-phenylpropanoic acid (565-07-1,6945-32-0)

Guidance literature:

With hydrogen bromide; acetic acid; phenol; at 75 ℃;

DOI:10.1021/ol061410g

Reference yield: 71.0%

(-)-N,N'-bis(benzyloxycarbonyl)-2-hydrazino-2-phenylpropionic acid methyl ester (929031-14-1) → 2-amino-2-phenylpropanoic acid (565-07-1,6945-32-0)

Guidance literature:

(-)-N,N'-bis(benzyloxycarbonyl)-2-hydrazino-2-phenylpropionic acid methyl ester; With pyridine; at 40 ℃; for 15h;

With trifluoroacetic anhydride; at 20 ℃; for 48h; Further stages;

DOI:10.1016/j.tetasy.2010.04.026

upstream raw materials:

sodium cyanide

acetophenone

α-amino-α-methylphenylacetonitrile

5-methyl-5-phenylimidazolidin-2,4-dione

Downstream raw materials:

p-Phenylazo-benzyloxycarbonyl-DL-α-phenyl-alanin

DL-α-Phenyl-alanin-tert-butylester

2-((tert-butoxycarbonyl)amino)-2-phenylpropanoic acid

N-Benzyloxycarbonyl-C-methyl-C-phenyl-glycin-<2-hydroxy-aethylamid>

Refernces

• 1、 Fernández-Nieto, Fernando,Mas Roselló, Josep,Lenoir, Simone,Hardy, Simon,Clayden, Jonathan. "Palladium Catalyzed C-Arylation of Amino Acid Derived Hydantoins". . p. 3838 - 3841. Retrieved 2015/08/18.
• 2、 Nunez, Marta G.,Farley, Alistair J. M.,Dixon, Darren J.. "Bifunctional iminophosphorane organocatalysts for enantioselective synthesis: Application to the ketimine nitro-Mannich reaction". . p. 16348 - 16351. Retrieved 2013/12/04.