4-PHENYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-PHENYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
• CAS No.: 261777-31-5
• Molecular Formula: C₁₇H₂₃NO₄
• Molecular Weight: 305.374
• Mol file: 261777-31-5.mol

Synonyms:N-BOC-4-PHENYL-PIPECOLIC ACID;4-PHENYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-(TERT-BUTOXYCARBONYL)-4-PHENYLPIPERIDINE-2-CARBOXYLIC ACID

Chemical Property of 4-PHENYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 454.9±45.0 °C(Predicted)
• PKA: 3.94±0.40(Predicted)
• PSA: 66.84000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 3.19220
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-4-phenylpiperidine-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PHENYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

There total 13 articles about 4-PHENYL-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester → C17H23NO4 (261777-31-5)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

C18H25NO4 → C17H23NO4 (261777-31-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 48h;

DOI:10.1021/acs.jmedchem.9b01953

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + tert-butyl 4-phenylpiperidine-1-carboxylate (123387-49-5) → (2R,4S)-cis-4-phenyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester (261777-38-2,261777-31-5)

Guidance literature:

tert-butyl 4-phenylpiperidine-1-carboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -20 ℃; for 0.5h;

carbon dioxide; In diethyl ether; cyclohexane; at -78 ℃; for 0.25h;

With L-tyrosine hydrazide; In methanol; Heating;

DOI:10.1016/S0957-4166(99)00473-5

upstream raw materials:

carbon dioxide

tert-butyl 4-phenylpiperidine-1-carboxylate

4-iodopyridine-2-carboxylic acid methyl ester

methyl 4-phenylpyridine-2-carboylate

Refernces

• 1、 -. "Allosteric modulators of 5-hydroxytryptamine 2C receptor (5-HT2CR)". . . Retrieved 2017/01/26.
• 2、 Keenan, Terence P.,Yaeger, David,Holt, Dennis A.. "Synthesis of chiral nonracemic 4-trans-substituted pipecolic acid derivatives". . p. 4331 - 4341. Retrieved 2007/10/03.