Technology Process of 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran
There total 10 articles about 4-acetyl-5-(3-acetoxypropyl)-7-methoxy-2-(3'-methoxy-4'-acetoxyphenyl)benzofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphoric acid; acetic acid;
at 100 ℃;
for 2h;
DOI:10.1021/jo00052a046
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 63 percent / POCl3 / 1) 0 deg C, 20 min, 2) 65 deg C, 10 h
2: 79 percent / NaOH / H2O; dioxane / 2 h / 80 °C
3: 1) CuSO4*H2O, NH4OH, NH2OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h
4: 92 percent / H2 / 5percent Pd-C / tetrahydrofuran / 10 h / Ambient temperature
5: 82 percent / LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature
6: 64 percent / gl. HOAc, 85percent H3PO4 / 2 h / 100 °C
With
pyridine; ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; phosphoric acid; hydroxylamine hydrochloride; hydrogen; copper(II) sulfate; acetic acid; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo00052a046
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 82 percent / Br2, HOAc / 1 h / Ambient temperature
2: 98 percent / pyrrolidine / pyridine / 6 h / 100 °C
3: 1) CuSO4*H2O, NH4OH, NH2OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h
4: 92 percent / H2 / 5percent Pd-C / tetrahydrofuran / 10 h / Ambient temperature
5: 82 percent / LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature
6: 64 percent / gl. HOAc, 85percent H3PO4 / 2 h / 100 °C
With
pyrrolidine; pyridine; ammonium hydroxide; lithium aluminium tetrahydride; phosphoric acid; hydroxylamine hydrochloride; hydrogen; bromine; copper(II) sulfate; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine;
DOI:10.1021/jo00052a046