5-(3-METHYLPHENYL)-1H-TETRAZOLE

Base Information

• Chemical Name: 5-(3-METHYLPHENYL)-1H-TETRAZOLE
• CAS No.: 3441-00-7
• Molecular Formula: C8H8 N4
• Molecular Weight: 160.178
• Hs Code.: 2933990090
• Mol file: 3441-00-7.mol

Synonyms:1H-Tetrazole,5-(3-methylphenyl)- (9CI); Tetrazole, 5-m-tolyl- (6CI,7CI,8CI);5-(3-Methylphenyl)-2H-tetrazole; 5-(3-Methylphenyl)tetrazole;5-m-Tolyltetrazole

Chemical Property of 5-(3-METHYLPHENYL)-1H-TETRAZOLE

Chemical Property:

• Vapor Pressure: 4.44E-05mmHg at 25°C
• Melting Point: 143-146°C
• Refractive Index: 1.604
• Boiling Point: 350.3°Cat760mmHg
• Flash Point: 168.8°C
• PSA: 54.46000
• Density: 1.241g/cm³
• LogP: 1.17510
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-(m-Tolyl)-1H-tetrazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3-METHYLPHENYL)-1H-TETRAZOLE

There total 10 articles about 5-(3-METHYLPHENYL)-1H-TETRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-Methylbenzonitrile (620-22-4) → 5-(3-methylphenyl)-1H-tetrazole (3441-00-7)

Guidance literature:

With sodium azide; copper(II) sulfate; In dimethyl sulfoxide; at 140 ℃; for 5h;

DOI:10.1590/S0103-50532013005000005

Reference yield: 93.2%

→ 5-(3-methylphenyl)-1H-tetrazole (3441-00-7)

Guidance literature:

Reference yield: 89.0%

3-Methylbenzonitrile (620-22-4) → 5-(m-tolyl)-2H-tetrazole (3441-00-7)

Guidance literature:

With sodium azide; triethylamine hydrochloride; In toluene; for 4h; Reflux;

upstream raw materials:

3-Methylbenzonitrile

azido tributyltin (IV)

meta-bromotoluene

3-methylbenzaldehyde oxime

Downstream raw materials:

2-methyl-5-m-tolyl-2H-tetrazole

2-trimethylsilylmethyl-5-(3-methylphenyl)-2H-tetrazole

(S)-4-(5-(m-tolyl)-2H-tetrazol-2-yl)octan-2-one

3-[5-(3-{5-[3-(5-m-tolyl-[1,3,4]oxadiazol-2-yl)-phenyl]-[1,3,4]oxadiazol-2-yl}-phenyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile

Refernces

• 1、 Ashraf, Muhammad Aqeel,Liu, Zhenling,Li, Cheng,Zhang, Dangquan. "Fe3O4@L-lysine-Pd(0) organic–inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles". . . Retrieved 2020/12/23.
• 2、 Pourhassan, Fatemeh,Eshghi, Hossein. "Novel Hybrid Thioamide Ligand Supported Copper Nanoparticles on SBA-15: A Copper Rich Robust Nanoreactor for Green Synthesis of Triazoles and Tetrazoles in Water Medium". . p. 1287 - 1300. Retrieved 2019/11/21.