PROSTAGLANDIN E1 METHYL ESTER

Base Information

• Chemical Name: PROSTAGLANDIN E1 METHYL ESTER
• CAS No.: 3434-33-1
• Molecular Formula: C21H36 O5
• Molecular Weight: 368.514
• Mol file: 3434-33-1.mol

Synonyms:Cyclopentaneheptanoicacid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, methyl ester, stereoisomer(8CI); Alprostadil methyl ester; Methyl prostaglandin E1; Prostaglandin E1methyl ester

Chemical Property of PROSTAGLANDIN E1 METHYL ESTER

Chemical Property:

• PSA: 83.83000
• LogP: 3.56350
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

PROSTAGLANDIN E1 METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36/37/38
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PROSTAGLANDIN E1 METHYL ESTER

There total 133 articles about PROSTAGLANDIN E1 METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

diazomethane (186581-53-3,908094-01-9,334-88-3) → prostaglandin E1 methyl ester (3434-33-1)

Guidance literature:

ALPROSTADIL; In diethyl ether; at 0 ℃;

diazomethane; In diethyl ether; at 20 ℃;

Reference yield: 95.0%

11,15-O-bis(tert-butyldimethylsilyl)PGE1 methyl ester (86982-75-4) → prostaglandin E1 methyl ester (3434-33-1)

Guidance literature:

With pyridine mixture; hydrogen fluoride; In acetonitrile; at 19 ℃; for 4h;

DOI:10.1021/ja00222a033

Reference yield: 92.0%

11,15-bis-O-(tetrahydropyran-2-yl)PGE1 methyl ester (77493-14-2) → prostaglandin E1 methyl ester (3434-33-1)

Guidance literature:

With water; acetic acid; In tetrahydrofuran; at 19 ℃; for 18h;

DOI:10.1246/bcsj.61.1299

upstream raw materials:

7-{5-oxo-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopent-1-en-1-yl}heptanoic acid methyl ester

(S)-3-(1-ethoxy-ethoxy)-1t-iodo-oct-1-ene

2-Methoxypropene

methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoate

Downstream raw materials:

ALPROSTADIL

Refernces

• 1、 Pappo et al.. "". . p. 943. Retrieved 1973.
• 2、 Hayashi, Yujiro,Umemiya, Shigenobu. "Pot economy in the synthesis of prostaglandin A1 and E 1 methyl esters". . p. 3450 - 3452. Retrieved 2013.
• 3、 -. "USE OF PROSTAGLANDIN E1 METHYL ESTER IN PREPARING VASODILATOR DRUG". Paragraph 0016-0018. . Retrieved 2021/10/07.
• 4、 Kamishima, Takaaki,Nonaka, Toshiyuki,Watanabe, Toshihiro,Koseki, Yoshitaka,Kasai, Hitoshi. "One-Step conversion to a disubstituted cyclopentenone from 2-Deoxy-D-Glucose and application to synthesis of prostaglandin e1 methyl ester". . p. 1691 - 1696. Retrieved 2018/11/27.