thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester

Base Information

• Chemical Name: thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester
• CAS No.: 862700-61-6
• Molecular Formula: C₁₂H₁₁F₅OS
• Molecular Weight: 298.277
• Mol file: 862700-61-6.mol

Synonyms:thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester

Chemical Property of thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester

There total 1 articles about thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiobenzoic acid (98-91-9) + 4,4,5,5,5-pentafluorpentan-1-ol (148043-73-6) → thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester (862700-61-6)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 83.0%

thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester (862700-61-6) + 9-bromononan-1-ol (55362-80-6) → 9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl alcohol (511545-94-1)

Guidance literature:

thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester; With potassium tert-butylate; In methanol; for 0.5h;

9-bromononan-1-ol;

Reference yield: 75.0%

thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester (862700-61-6) + 1-(5-iodopentyl)-5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione (1252642-93-5) → 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-1-{5-[(4,4,5,5,5-pentafluoropentyl)thio]pentyl}imidazolidine-2,4-dione (1252642-92-4)

Guidance literature:

thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester; With potassium tert-butylate; In methanol; at 23 ℃; for 0.5h; Inert atmosphere;

1-(5-iodopentyl)-5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione; In methanol; for 24h; Inert atmosphere;

upstream raw materials:

thiobenzoic acid

4,4,5,5,5-pentafluorpentan-1-ol

Downstream raw materials:

9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl alcohol

5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-1-{5-[(4,4,5,5,5-pentafluoropentyl)thio]pentyl}imidazolidine-2,4-dione

3,17β-bis(2-tetrahydropyranyloxy)-7α-[9-(4,4,5,5,5-pentafluoropentyl)thiononyl]estra-1,3,5(10)-triene-6-one

fulvestrant

Refernces

• 1、 -. "STEROIDS FOR CANCER TREATMENT". Page/Page column 32-33. . Retrieved 2010/02/13.