4-BROMO-2,5-DIMETHOXYBENZOIC ACID

Base Information

• Chemical Name: 4-BROMO-2,5-DIMETHOXYBENZOIC ACID
• CAS No.: 35458-39-0
• Molecular Formula: C9H9BrO4
• Molecular Weight: 261.072
• Hs Code.: 2918990090
• Mol file: 35458-39-0.mol

Synonyms:4-Bromo-2,5-dimethoxybenzoic acid;4-Bromo-2,5-dimethoxy-benzoic acid;

Chemical Property of 4-BROMO-2,5-DIMETHOXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.566
• Boiling Point: 358.78 °C at 760 mmHg
• Flash Point: 170.784 °C
• PSA: 55.76000
• Density: 1.571 g/cm³
• LogP: 2.16450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-BROMO-2,5-DIMETHOXYBENZOICACID 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2,5-DIMETHOXYBENZOIC ACID

There total 9 articles about 4-BROMO-2,5-DIMETHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromo-2,5-dimethoxybenzaldehyde (31558-41-5) → 4-bromo-2,5-dimethoxybenzoic acid (35458-39-0)

Guidance literature:

With sodium hypochlorite; disodium hydrogenphosphate; dihydrogen peroxide; In water; acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja204040k

Reference yield: 92.0%

carbon dioxide (124-38-9,18923-20-1) + 1,4-dibromo-2,5-dimethoxybenzene (2674-34-2) → 4-bromo-2,5-dimethoxybenzoic acid (35458-39-0)

Guidance literature:

1,4-dibromo-2,5-dimethoxybenzene; With TurboGrignard; In tetrahydrofuran; at 25 ℃; for 2.75h; Inert atmosphere; Large scale;

carbon dioxide; In tetrahydrofuran; at -40 - -39 ℃; for 3.5h; Inert atmosphere; Large scale;

DOI:10.1021/acs.oprd.5b00404

Reference yield:

2,5-dimethoxybenzaldehyde (93-02-7) → 4-bromo-2,5-dimethoxybenzoic acid (35458-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂, SnCl₄

2: KMnO₄

With potassium permanganate; bromine; tin(IV) chloride;

DOI:10.1021/jm00286a026

upstream raw materials:

1-bromo-2,5-dimethoxy-4-methylbenzene

4-bromo-2,5-dimethoxybenzaldehyde

carbon dioxide

1,4-dibromo-2,5-dimethoxybenzene

Downstream raw materials:

4-bromo-2,5-dihydroxybenzoic acid

4-hydroxy-2,5-dimethoxybenzoic acid benzyl ester

C₂₄H₃₂O₉

C₃₄H₄₆N₂O₁₁S

Refernces

• 1、 Coombs, Gavin,Sak, Marcus H.,Miller, Scott J.. "Peptide-Catalyzed Fragment Couplings that Form Axially Chiral Non-C2-Symmetric Biaryls". supporting information. p. 2875 - 2880. Retrieved 2020/01/24.
• 2、 Zhang, Wu-Yan,Sun, Cuixiang,Hunt, Diana,He, Minsheng,Deng, Yonghong,Zhu, Zhijian,Chen, Chi-Li,Katz, Christopher E.,Niu, John,Hogan, Philip C.,Xiao, Xiao-Yi,Dunwoody, Nicholas,Ronn, Magnus. "Process Development and Scale-up of Fully Synthetic Tetracycline TP-2758: A Potent Antibacterial Agent with Excellent Oral Bioavailability". . p. 284 - 296. Retrieved 2016/03/04.