2-(Pyridin-4-yloxy)ethanamine

Base Information

• Chemical Name: 2-(Pyridin-4-yloxy)ethanamine
• CAS No.: 259816-44-9
• Molecular Formula: C7H10 N2 O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40478284
• Mol file: 259816-44-9.mol

Synonyms:2-(Pyridin-4-yloxy)ethanamine;259816-44-9;2-(Pyridin-4-yloxy)-ethylamine;2-pyridin-4-yloxyethanamine;2-(pyridin-4-yloxy)ethan-1-amine;Ethanamine,2-(4-Pyridinyloxy);2-(4-Pyridinyloxy)ethanamine;2-(4-Pyridinyloxy)-ethanamine;2-(pyridin-4-yloxy)ethylamine;SCHEMBL1623962;DTXSID40478284;YSUKTUWMBAKSSV-UHFFFAOYSA-N;MFCD16714126;AKOS011634636;SB36244;TS-01793;Ethanamine, 2-(4-pyridinyloxy)- (9CI);CS-0096297;EN300-1840967;A877404

Chemical Property of 2-(Pyridin-4-yloxy)ethanamine

Chemical Property:

• Boiling Point: 258.8±20.0 °C(Predicted)
• PKA: 7.76±0.10(Predicted)
• PSA: 48.14000
• Density: 1.089±0.06 g/cm3(Predicted)
• LogP: 1.11940
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 81.7

Purity/Quality:

98%min ^*data from raw suppliers

2-(Pyridin-4-yloxy)ethanamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1OCCN

Technology Process of 2-(Pyridin-4-yloxy)ethanamine

There total 4 articles about 2-(Pyridin-4-yloxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorpyridine hydrochloride (7379-35-3) + ethanolamine (141-43-5) → 2-(pyridin-4-yloxy)ethan-1-amine (259816-44-9)

Guidance literature:

With sodium hydride; at 20 - 60 ℃; for 17h;

DOI:10.1016/j.bmc.2004.05.021

Reference yield:

4-(2-phthalimidoethyloxy)pyridine (155966-39-5) → 2-(pyridin-4-yloxy)ethan-1-amine (259816-44-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 50 ℃; for 4h;

DOI:10.1021/acsmedchemlett.8b00177

Reference yield:

pyridin-4-ol (626-64-2,157061-69-3) → 2-(pyridin-4-yloxy)ethan-1-amine (259816-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / ethanol / 4 h / 50 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/acsmedchemlett.8b00177

upstream raw materials:

4-chlorpyridine hydrochloride

ethanolamine

pyridin-4-ol

4-(2-phthalimidoethyloxy)pyridine

Refernces

• 1、 -. "SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS". Page/Page column 34; 44; 45. . Retrieved 2015/06/03.
• 2、 -. "Tnf-alpha production inhibitors". . . Retrieved 2008/06/13.