Technology Process of 15-benzyloxy-(8Z,11Z,13E,15S)-8,11,13-eicosatrienoic acid
There total 18 articles about 15-benzyloxy-(8Z,11Z,13E,15S)-8,11,13-eicosatrienoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(7-carboxyheptyl)triphenylphosphonium bromide;
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -30 ℃;
for 1h;
7-benzyloxy-(3Z,5E,7S)-3,5-dodecadien-1-al;
In
tetrahydrofuran;
at -30 - 20 ℃;
DOI:10.1016/S0957-4166(03)00369-0
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 60 percent / PTSA / CH2Cl2 / 0.5 h
2.1: 90 percent / (COCl)2; DMSO; Et3N / dimethylsulfoxide; CH2Cl2 / -78 - 25 °C
3.1: n-BuLi; HMPA / tetrahydrofuran; hexane / 1 h / 0 °C
3.2: tetrahydrofuran; hexane / 0 °C
4.1: PTSA / methanol / 1 h / 20 °C
5.1: 75 percent / Jones reagent / acetone / 0 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; jones reagent; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; acetone;
2.1: Swern oxidation / 3.2: Wittig reaction / 5.1: Jones oxidation;
DOI:10.1016/S0957-4166(03)00369-0
