1,1-di-(perfluoro n-propyl) ethanol-⁽¹⁾

Base Information

• Chemical Name: 1,1-di-(perfluoro n-propyl) ethanol-⁽¹⁾
• CAS No.: 375-86-0
• Molecular Formula: C₈H₄F₁₄O
• Molecular Weight: 382.097
• Mol file: 375-86-0.mol

Synonyms:1,1-di-(perfluoro n-propyl) ethanol-⁽¹⁾

Chemical Property of 1,1-di-(perfluoro n-propyl) ethanol-⁽¹⁾

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1,1-di-(perfluoro n-propyl) ethanol-⁽¹⁾

There total 4 articles about 1,1-di-(perfluoro n-propyl) ethanol-⁽¹⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

(heptafluoro n-propyl) magnesiumiodide (423-25-6) + acetyl chloride (75-36-5) → 1,1-di-(perfluoro n-propyl) ethanol-(1) (375-86-0) + heptafluoropropyl methyl ketone (355-17-9)

Guidance literature:

In further solvent(s); reaction in n-butyl ether at -20°C, 3 hours, stirring for 24 hours, warming to 20°C within 12 - 15 hours and heating to 50°C, 0.5 hours;;

Reference yield: 12.0%

(heptafluoro n-propyl) magnesiumiodide (423-25-6) + ethyl acetate (141-78-6) → 3,3,4,4,5,5,5-heptafluoro-2-pentanol (375-14-4,85571-83-1) + 1,1-di-(perfluoro n-propyl) ethanol-(1) (375-86-0) + heptafluoropropyl methyl ketone (355-17-9)

Guidance literature:

In further solvent(s); addition of the grignard solution to the ester (solution in n-butyl ether) at -50°C, stirring at -40°C, 24 hours, warming to 20°C within 24 hours and stirring for 24 hours;;

Reference yield:

diethyl ether (60-29-7,927820-24-4) + ethyl acetate (141-78-6) → 3,3,4,4,5,5,5-heptafluoro-2-pentanol (375-14-4,85571-83-1) + 1,1-di-(perfluoro n-propyl) ethanol-(1) (375-86-0) + heptafluoropropyl methyl ketone (355-17-9)

Guidance literature:

DOI:10.1111/j.1467-842X.2001.tb00592.x

upstream raw materials:

1,1,1,2,2,3,3-heptafluoro-3-iodo-propane

perfluoro-4-heptanone

methyllithium

diethyl ether