2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Base Information

• Chemical Name: 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
• CAS No.: 170171-53-6
• Molecular Formula: C₄₆H₅₄Cl₃NO₁₆
• Molecular Weight: 983.291
• Mol file: 170171-53-6.mol

Synonyms:2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Chemical Property of 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

There total 1 articles about 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel (170171-53-6)

Guidance literature:

With pyridine;

DOI:10.1021/jm00107a017

Reference yield: 87.0%

2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel (170171-53-6) + valeric acid (109-52-4) → 7,10-di-O-valeryl-2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; at 70 ℃; for 2h;

DOI:10.1016/S0968-0896(99)00279-5

Reference yield: 76.0%

4-(2,2,2-trichloroethoxy)-4-oxobutanoic acid (6136-22-7) + 2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel (170171-53-6) → 7,10-di-O-(2,2,2-trichloroethyl succinyl)-2'-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In toluene; at 70 ℃; for 2h;

DOI:10.1016/S0968-0896(99)00279-5

upstream raw materials:

Docetaxel

2,2,2-Trichloroethyl chloroformate

Refernces