2-(benzyloxy)-5-bromo-6-methylnicotinonitrile

Base Information

• Chemical Name: 2-(benzyloxy)-5-bromo-6-methylnicotinonitrile
• CAS No.: 1265919-11-6
• Molecular Formula: C₁₄H₁₁BrN₂O
• Molecular Weight: 303.158
• Mol file: 1265919-11-6.mol

Synonyms:2-(benzyloxy)-5-bromo-6-methylnicotinonitrile

Chemical Property of 2-(benzyloxy)-5-bromo-6-methylnicotinonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(benzyloxy)-5-bromo-6-methylnicotinonitrile

There total 1 articles about 2-(benzyloxy)-5-bromo-6-methylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl bromide (100-39-0) + 5-bromo-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (84725-13-3) → 2-(benzyloxy)-5-bromo-6-methylnicotinonitrile (1265919-11-6)

Guidance literature:

With silver carbonate; In tetrahydrofuran; at 66 ℃; for 5h; Darkness;

DOI:10.1002/adsc.201000592

Reference yield: 92.0%

2-(benzyloxy)-5-bromo-6-methylnicotinonitrile (1265919-11-6) + 4-pyridylboronic acid (1692-15-5) → 6-(benzyloxy)-2-methyl-3,4'-bipyridine-5-carbonitrile (1265919-16-1)

Guidance literature:

With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydrogencarbonate; In ethanol; dichloromethane; water; at 100 ℃; for 12h;

DOI:10.1002/adsc.201000592

Reference yield: 87.0%

2-(benzyloxy)-5-bromo-6-methylnicotinonitrile (1265919-11-6) + 3-pyridylboronic acid (1692-25-7) → 6-(benzyloxy)-2-methyl-3,3'-bipyridine-5-carbonitrile (1265919-09-2)

Guidance literature:

With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydrogencarbonate; In dichloromethane; toluene; at 100 ℃; for 5h; Reflux;

DOI:10.1002/adsc.201000592

upstream raw materials:

benzyl bromide

5-bromo-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Downstream raw materials:

6-(benzyloxy)-2-methyl-3,3'-bipyridine-5-carbonitrile

6-(benzyloxy)-2-methyl-3,4'-bipyridine-5-carbonitrile

Refernces