Technology Process of selenide
There total 5 articles about selenide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-arylbutanolide;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
then stirring of the resulted mixture at -78 deg C over 1.5 h;
Phenylselenyl chloride;
In
tetrahydrofuran;
at -78 ℃;
then warming of the reaction mixture to 0 deg C over a period 2.5 h;
DOI:10.1080/00397919808004439
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 98 percent / piperidine; benzoic acid / benzene / refluxing overnight under an argon atmosphere with Dean-Stark trap
2.1: 70 percent / ethanol; H2O / 70 °C / stirring overnight at 70 deg C
3.1: 74 percent / n.BuLi; diisobutylaluminium (DIBAL); sodium borohydride / tetrahydrofuran; hexane; ethanol / 4 h / -78 - 0 °C / warming to room temperature over 1 h
4.1: 65 percent / sulfuric acid / aq. ethanol / 24 h / reflux
5.1: n.BuLi; diisopropylamine / tetrahydrofuran; hexane / -78 °C / then stirring of the resulted mixture at -78 deg C over 1.5 h
5.2: 71 percent / tetrahydrofuran / -78 °C / then warming of the reaction mixture to 0 deg C over a period 2.5 h
With
sodium tetrahydroborate; n-butyllithium; sulfuric acid; Diisobutylaluminium hydride(1 M solution in tetrahydrofuran, 4.9 mL, 4.9 mmol); diisopropylamine;
piperidine; benzoic acid;
In
tetrahydrofuran; ethanol; hexane; water; benzene;
1.1: Condensation / 2.1: Cyanidation / 3.1: Reduction / 4.1: Cyclization / 5.1: Metallation / 5.2: Substitution;
DOI:10.1080/00397919808004439
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 70 percent / ethanol; H2O / 70 °C / stirring overnight at 70 deg C
2.1: 74 percent / n.BuLi; diisobutylaluminium (DIBAL); sodium borohydride / tetrahydrofuran; hexane; ethanol / 4 h / -78 - 0 °C / warming to room temperature over 1 h
3.1: 65 percent / sulfuric acid / aq. ethanol / 24 h / reflux
4.1: n.BuLi; diisopropylamine / tetrahydrofuran; hexane / -78 °C / then stirring of the resulted mixture at -78 deg C over 1.5 h
4.2: 71 percent / tetrahydrofuran / -78 °C / then warming of the reaction mixture to 0 deg C over a period 2.5 h
With
sodium tetrahydroborate; n-butyllithium; sulfuric acid; Diisobutylaluminium hydride(1 M solution in tetrahydrofuran, 4.9 mL, 4.9 mmol); diisopropylamine;
In
tetrahydrofuran; ethanol; hexane; water;
1.1: Cyanidation / 2.1: Reduction / 3.1: Cyclization / 4.1: Metallation / 4.2: Substitution;
DOI:10.1080/00397919808004439
