N-ME-VAL-OME HCL

Base Information

• Chemical Name: N-ME-VAL-OME HCL
• CAS No.: 3339-44-4
• Molecular Formula: C7H15 N O2 . Cl H
• Molecular Weight: 181.663
• Hs Code.: 2922499990
• Mol file: 3339-44-4.mol

Synonyms:L-Valine,N-methyl-, methyl ester, hydrochloride (9CI); Valine, N-methyl-, methyl ester,hydrochloride (7CI); Valine, N-methyl-, methyl ester, hydrochloride, L- (8CI);N-Methylvaline methyl ester hydrochloride

Chemical Property of N-ME-VAL-OME HCL

Chemical Property:

• Melting Point: 140-141℃
• PSA: 38.33000
• LogP: 1.59630
• Storage Temp.: Store at RT.

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-L-valine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Me-Val-OMe HCl is a useful reactant for the synthesis of various organic compounds such as etrapeptide belamide A, and 2-?chloro-?1,?3-?dimethyl-?1H-?benzimidazolium hexafluorophosphate (CMBI)?.

Technology Process of N-ME-VAL-OME HCL

There total 14 articles about N-ME-VAL-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + Boc-N-Me-Val-OH (45170-31-8) → methyl N-methyl-L-valinate hydrochloride (3339-44-4)

Guidance literature:

With thionyl chloride; for 16h; Reflux;

DOI:10.3762/bjoc.8.234

Reference yield: 96.0%

methyl (2S)-2-[(tert-butoxycarbonyl)(methyl)amino]-3-methylbutanoate (24164-06-5) → methyl N-methyl-L-valinate hydrochloride (3339-44-4)

Guidance literature:

With hydrogenchloride; water; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1002/chem.201002063

Reference yield: 72.0%

methanol (67-56-1) + (S)-4-Isopropyl-3-methyl-2,2-bis-trifluoromethyl-oxazolidin-5-one (202273-45-8) → methyl N-methyl-L-valinate hydrochloride (3339-44-4)

Guidance literature:

With hydrogenchloride; Ambient temperature;

DOI:10.1055/s-1998-1998

upstream raw materials:

methanol

Z-MeVal-OH

2-(N-benzyloxycarbonyl-N-methylamino)-3-methylbutyric acid methyl ester

methyl (2S)-2-[(tert-butoxycarbonyl)(methyl)amino]-3-methylbutanoate

Downstream raw materials:

(S)-benzyl 2-(2-(2-(tert-butoxycarbonylamino)-N-methylacetamido)-3-methyl-butanamido)benzoate

(S)-benzyl 2-(2-(2-amino-N-methylacetamido)-3-methylbutanamido)benzoate 2,2,2-trifluoroacetate

(S)-benzyl 2-(2-(2-(2-(dimethylamino)benzamido)-N-methylacetamido)-3-methylbutanamido)benzoate

(S)-2-(2-(2-(2-(dimethylamino)benzamido)-N-methylacetamido)-3-methylbutanamido)benzoic acid

Refernces

• 1、 Lan, Hong-Qiao,Ye, Jian-Liang,Wang, Ai-E,Ruan, Yuan-Ping,Huang, Pei-Qiang. "A flexible asymmetric approach to methyl 5-alkyltetramates and its application in the synthesis of cytotoxic marine natural product belamide A". experimental part. p. 958 - 968. Retrieved 2011/03/20.
• 2、 Li, Peng,Xu, Jie-Cheng. "1-Ethyl 2-halopyridinium salts, highly efficient coupling reagents for hindered peptide synthesis both in solution and the solid-phase". . p. 8119 - 8131. Retrieved 2007/10/03.