6-CHLORO-4-AMINO-2-METHOXYPYRIMIDINE

Base Information

• Chemical Name: 6-CHLORO-4-AMINO-2-METHOXYPYRIMIDINE
• CAS No.: 3286-55-3
• Molecular Formula: C5H6 Cl N3 O
• Molecular Weight: 159.575
• Hs Code.: 2933599090
• Mol file: 3286-55-3.mol

Synonyms:Pyrimidine,4-amino-6-chloro-2-methoxy- (6CI,7CI,8CI);2-Methoxy-4-amino-6-chloropyrimidine; 4-Amino-6-chloro-2-methoxypyrimidine

Chemical Property of 6-CHLORO-4-AMINO-2-METHOXYPYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.000102mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 337.8ºC at 760 mmHg
• Flash Point: 158.1ºC
• PSA: 61.03000
• Density: 1.398g/cm3
• LogP: 1.30200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-2-methoxypyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-4-AMINO-2-METHOXYPYRIMIDINE

There total 2 articles about 6-CHLORO-4-AMINO-2-METHOXYPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-amino-2,6-dichloropyrimidine (10132-07-7) + sodium methylate (124-41-4) → 6-chloro-2-methoxypyrimidin-4-amine (3286-55-3)

Guidance literature:

In methanol; for 2h; Heating / reflux;

Reference yield:

→ 6-chloro-2-methoxypyrimidin-4-amine (3286-55-3)

Guidance literature:

2,6-Dichlor-4-amino-pyrimidin, Me., NaOCH3-Lsg., 35-50grad;

DOI:10.1007/BF00914083

Reference yield: 99.0%

6-chloro-2-methoxypyrimidin-4-amine (3286-55-3) + phenylboronic acid (98-80-6) → 2-methoxy-6-phenylpyrimidin-4-amine

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); caesium carbonate; In water; toluene; at 115 ℃; for 16h;

upstream raw materials:

4-amino-2,6-dichloropyrimidine

sodium methylate

Refernces