5-ethynyl-2-hydroxyacetophenone

Base Information

• Chemical Name: 5-ethynyl-2-hydroxyacetophenone
• CAS No.: 1350803-03-0
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.172
• Mol file: 1350803-03-0.mol

Synonyms:5-ethynyl-2-hydroxyacetophenone

Chemical Property of 5-ethynyl-2-hydroxyacetophenone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-ethynyl-2-hydroxyacetophenone

There total 7 articles about 5-ethynyl-2-hydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(2-hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethan-1-one (1450713-16-2) → 5-ethynyl-2-hydroxyacetophenone (1350803-03-0)

Guidance literature:

With methanol; potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.5560/ZNB.2013-2332

Reference yield: 94.0%

C16H12O3 → 5-ethynyl-2-hydroxyacetophenone (1350803-03-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c6cc07119h

Reference yield: 47.0%

2'-hydroxy-5'-(3-hydroxy-3-methyl-1-butynyl)acetophenone (1446428-57-4) → 5-ethynyl-2-hydroxyacetophenone (1350803-03-0)

Guidance literature:

With potassium hydroxide; In toluene; for 3h; Reflux;

DOI:10.5560/ZNB.2013-2332

upstream raw materials:

2'-hydroxy-5'-(3-hydroxy-3-methyl-1-butynyl)acetophenone

4-bromo-phenol

4-bromophenyl acetate

5-Bromo-2-hydroxyacetophenone

Downstream raw materials:

5,5'-[benzene-1,4-diyl-di(ethyne-2,1-diyl)]bis(2-hydroxyacetophenone)

5,5'-(ethyne-1,2-diyl)bis(2-hydroxyacetophenone)

2,4-diacetylphenol

Refernces

• 1、 Huebscher, Joerg,Guenthel, Michael,Rosin, Robert,Seichter, Wilhelm,Mertens, Florian,Weber, Edwin. "Synthesis and structural characterisation of new bifunctional o-hydroxyacetophenones - Potential linker molecules for coordinative framework construction". . p. 214 - 222. Retrieved 2013/06/27.