Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate

Base Information

• Chemical Name: Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate
• CAS No.: 124831-11-4
• Molecular Formula: C₁₁H₁₅ClNO₅P
• Molecular Weight: 307.671
• Mol file: 124831-11-4.mol

Synonyms:Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate

Chemical Property of Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate

There total 1 articles about Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-4-(2-nitrovinyl)benzene (706-07-0,5153-70-8) + dimethyl methane phosphonate (756-79-6) → Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate (124831-11-4)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h, 2.) -78 deg C -> room temp.;

DOI:10.1055/s-1989-27279

Reference yield:

Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate (124831-11-4) → Dimethyl 3-amino-2-(4-chlorophenyl)propylphosphonate (124831-12-5)

Guidance literature:

With ammonium hydroxide; hydrogen; nickel; In ethanol; under 750.06 Torr; Yield given;

DOI:10.1055/s-1989-27279

Reference yield:

Dimethyl 2-(4-chlorophenyl)-3-nitropropylphosphonate (124831-11-4) → phaclofen (114012-12-3,108351-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, 8percent NH₃ / Raney Nickel / ethanol / 750.06 Torr

2: 61 percent / 36percent aq. HCl / 15 h / Heating

With hydrogenchloride; ammonium hydroxide; hydrogen; nickel; In ethanol;

DOI:10.1055/s-1989-27279

upstream raw materials:

1-chloro-4-(2-nitrovinyl)benzene

dimethyl methane phosphonate

Downstream raw materials:

Dimethyl 3-amino-2-(4-chlorophenyl)propylphosphonate

phaclofen

Refernces