1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE

Base Information

• Chemical Name: 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE
• CAS No.: 3226-34-4
• Molecular Formula: C8H7 Cl O2
• Molecular Weight: 170.595
• Hs Code.: 2914700090
• Mol file: 3226-34-4.mol

Synonyms:Acetophenone,3'-chloro-2'-hydroxy- (7CI,8CI); 1-(3-Chloro-2-hydroxyphenyl)ethanone;3'-Chloro-2'-hydroxyacetophenone

Chemical Property of 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE

Chemical Property:

• Vapor Pressure: 0.0167mmHg at 25°C
• Melting Point: 80 °C
• Refractive Index: 1.569
• Boiling Point: 247.1°Cat760mmHg
• PKA: 8.69±0.10(Predicted)
• Flash Point: 103.2°C
• PSA: 37.30000
• Density: 1.298g/cm³
• LogP: 2.24820
• Storage Temp.: -20°C Freezer
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99%, ^*data from raw suppliers

2’-Hydroxy-3-chloroacetophenone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2’-Hydroxy-3-chloroacetophenone (cas# 3226-34-4) is a compound useful in organic synthesis.

Technology Process of 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE

There total 11 articles about 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-chloro-2-hydroxyacetophenone oxime (42524-22-1) → 1-(3-chloro-2-hydroxyphenyl)ethanone (3226-34-4)

Guidance literature:

With sodium perborate; In acetic acid; for 5.5h; Heating;

DOI:10.1080/00397910008087181

Reference yield: 53.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) → 5-chloro-2-hydroxyacetophenone (1450-74-4) + 1-(3,5-dichloro-2-hydroxyphenyl)-ethanone (3321-92-4) + 1-(3-chloro-2-hydroxyphenyl)ethanone (3226-34-4)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; sulfuryl dichloride; at 100 ℃; for 0.75h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo402424h

Reference yield: 32.0%

2-chlorophenyl acetate (4525-75-1) → 1-(3-chloro-2-hydroxyphenyl)ethanone (3226-34-4)

Guidance literature:

With aluminum (III) chloride; In 1,2-dichloro-benzene; Inert atmosphere; Heating;

DOI:10.1021/acs.jnatprod.8b00258

upstream raw materials:

2-chlorophenyl acetate

2-monochlorophenol

acetyl chloride

3-chloro-2-hydroxyacetophenone oxime

Downstream raw materials:

3'-chloro-2,2'-dihydroxy-trans-chalcone

7-chloro-3-methyl-2-benzofuryl phenyl ketone

(7-chloro-3-methyl-benzofuran-2-yl)-(4-chloro-phenyl)-ketone

2-chloro-6-acetylphenyl methyl ether

Refernces

• 1、 -. "Hydroximoyl-tetrazole derivative fungicide". Paragraph 0267; 0269; 0270. . Retrieved 2019/02/19.
• 2、 -. "Photocatalytic benzene and benzene derivative direct hydroxylation or amination method". Paragraph 0126-0127. . Retrieved 2017/11/29.