methyl-5 phenyl-2 p-tolyl-3 benzofuranne

Base Information

• Chemical Name: methyl-5 phenyl-2 p-tolyl-3 benzofuranne
• CAS No.: 116544-80-0
• Molecular Formula: C₂₂H₁₈O
• Molecular Weight: 298.384
• Mol file: 116544-80-0.mol

Synonyms:methyl-5 phenyl-2 p-tolyl-3 benzofuranne

Chemical Property of methyl-5 phenyl-2 p-tolyl-3 benzofuranne

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl-5 phenyl-2 p-tolyl-3 benzofuranne

There total 12 articles about methyl-5 phenyl-2 p-tolyl-3 benzofuranne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

para-bromotoluene (106-38-7) + 1-methoxy-4-methyl-2-(2-phenylethynyl)benzene (1191950-68-1) → methyl-5 phenyl-2 p-tolyl-3 benzofuranne (116544-80-0)

Guidance literature:

1-methoxy-4-methyl-2-(2-phenylethynyl)benzene; With boron trichloride; In dichloromethane; at 20 ℃; for 0.166667h; Schlenk technique;

para-bromotoluene; With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; at 80 ℃; for 12h;

DOI:10.1002/anie.201610014

Reference yield:

1-Phenyl-2-p-tolyl-2-p-tolyloxy-ethanone (116544-75-3) → methyl-5 phenyl-2 p-tolyl-3 benzofuranne (116544-80-0)

Guidance literature:

With PPA; at 120 ℃; Yield given;

Reference yield:

p-cresyl benzoate (614-34-6) → methyl-5 phenyl-2 p-tolyl-3 benzofuranne (116544-80-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Br₂, AlCl₃ / 10 h / 180 °C

2: 30percent aq. HCl / 120 °C

3: 75 percent / K₂CO₃ / butan-2-one / 3 h / Heating

4: 2 N Na₂CO₃ / ethanol / 1 h / Heating

5: NaOAc, Ac₂O / 1 h / Heating

With hydrogenchloride; aluminium trichloride; bromine; sodium acetate; acetic anhydride; sodium carbonate; potassium carbonate; In ethanol; butanone;

upstream raw materials:

α-(p-Tolyloxy)-4-methyldesoxybenzoin

1-Phenyl-2-p-tolyl-2-p-tolyloxy-ethanone

[4-Methyl-2-(4-methyl-benzoyl)-phenoxy]-phenyl-acetic acid

p-cresyl benzoate

Refernces

• 1、 Montfort, Bernard,Laude, Bernard,Vebrel, Joel,Cerutti, Ernest. "Cyclodeshydratation d'aryloxy-2 diaryl-1,2 ethanones en diaryl-2,3 benzofurannes. Influence de la substitution sur la competition entre deux chemins reactionnels". . p. 848 - 854. Retrieved 2007/10/02.