ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride

Base Information

• Chemical Name: ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride
• CAS No.: 251349-56-1
• Molecular Formula: C₁₀H₁₄N₂O₂S
• Molecular Weight: 226.299
• Hs Code.: 2934100090
• Mol file: 251349-56-1.mol

Synonyms:(S)-2-Pyrrolidin-2-ylthiazole-4-carboxylicacid ethyl ester

Chemical Property of ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 4.39E-06mmHg at 25°C
• Boiling Point: 378°C at 760 mmHg
• PKA: 7.95±0.10(Predicted)
• Flash Point: 182.4°C
• PSA: 79.46000
• Density: 1.216
• LogP: 2.87510

Purity/Quality:

98%min ^*data from raw suppliers

R-Ethyl 2-(pyrrolidine-2-yl)thiazole-4-carboxylate hydrochloride >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride

There total 4 articles about ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl (S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate (212009-06-8) → (S)-2-Pyrrolidin-2-yl-thiazole-4-carboxylic acid ethyl ester (251349-56-1)

Guidance literature:

With trifluoroacetic acid; In methoxybenzene; at 0 ℃;

DOI:10.1002/(SICI)1521-4184(19999)332:9<297::AID-ARDP297>3.0.CO;2-#

Reference yield:

ethyl Bromopyruvate (70-23-5) → (S)-2-Pyrrolidin-2-yl-thiazole-4-carboxylic acid ethyl ester (251349-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KHCO₃ / 1,2-dimethoxy-ethane / 0.02 h

2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 0 - 20 °C

3: 96 percent / TFA / methoxybenzene / 0 °C

With pyridine; potassium hydrogencarbonate; trifluoroacetic acid; trifluoroacetic anhydride; In 1,2-dimethoxyethane; methoxybenzene; 1: Cyclization / 2: Dehydration / 3: Decarboxylation;

DOI:10.1002/(SICI)1521-4184(19999)332:9<297::AID-ARDP297>3.0.CO;2-#

Reference yield:

tert‐butyl (S)‐2‐carbamothioylpyrrolidine‐1‐carboxylate (117175-41-4,101410-18-8) → (S)-2-Pyrrolidin-2-yl-thiazole-4-carboxylic acid ethyl ester (251349-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KHCO₃ / 1,2-dimethoxy-ethane / 0.02 h

2: trifluoroacetic anhydride; pyridine / 1,2-dimethoxy-ethane / 0 - 20 °C

3: 96 percent / TFA / methoxybenzene / 0 °C

With pyridine; potassium hydrogencarbonate; trifluoroacetic acid; trifluoroacetic anhydride; In 1,2-dimethoxyethane; methoxybenzene; 1: Cyclization / 2: Dehydration / 3: Decarboxylation;

DOI:10.1002/(SICI)1521-4184(19999)332:9<297::AID-ARDP297>3.0.CO;2-#

upstream raw materials:

ethyl (S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate

ethyl Bromopyruvate

tert‐butyl (S)‐2‐carbamothioylpyrrolidine‐1‐carboxylate

Refernces