Trimipramine N-oxide

Base Information

• Chemical Name: Trimipramine N-oxide
• CAS No.: 14171-70-1
• Molecular Formula: C₂₀H₂₆N₂O
• Molecular Weight: 310.439
• European Community (EC) Number: 641-958-5
• UNII: TUI5X0O724
• DSSTox Substance ID: DTXSID10891486
• Wikidata: Q27290394
• Mol file: 14171-70-1.mol

Synonyms:Trimipramine N-oxide;14171-70-1;Trimipramine N-oxide, (+/-)-;UNII-TUI5X0O724;TUI5X0O724;Trimipramine maleate specified impurity A [EP];3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine oxide;(2RS)-3-(10,11-Dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N,2-trimethylpropan-1-amine N-oxide;Trimipramine maleate impurity, trimipramine N-oxide- [USP];5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, N-oxide;(2RS)-3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine N-oxide (Trimipramine N-Oxide);Trimipramine N-Oxid;Trimipramine-N-oxide;DTXSID10891486;HY-147333;CS-0566025;NS00000654;Q27290394;TRIMIPRAMINE MALEATE IMPURITY A [EP IMPURITY];TRIMIPRAMINE MALEATE IMPURITY, TRIMIPRAMINE N-OXIDE- [USP IMPURITY];5H-DIBENZ(B,F)AZEPINE-5-PROPANAMINE, 10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-, N-OXIDE;Trimipramine Maleate Imp. A (EP);Trimipramine Imp. A (EP);(2RS)-3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine N-oxide;Trimipramine N-Oxide;Trimipramine Maleate Impurity A;Trimipramine Impurity A

Chemical Property of Trimipramine N-oxide

Chemical Property:

• Melting Point: 115-117°C
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 310.204513457
• Heavy Atom Count: 23
• Complexity: 360

Purity/Quality:

97% ^*data from raw suppliers

Trimipramine N-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1C2=CC=CC=C2CCC3=CC=CC=C31)C[N+](C)(C)[O-]
• Uses: A metabolite of Trimipramine (T799000).

Technology Process of Trimipramine N-oxide

There total 2 articles about Trimipramine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimipramine (739-71-9) → trimipramine N-oxide (14171-70-1)

Guidance literature:

With dihydrogen peroxide; In methanol; for 168h;

DOI:10.1016/j.tetlet.2010.08.045

Reference yield:

→ trimipramine N-oxide (14171-70-1)

Guidance literature:

aus d. Amin und H2O2;

Reference yield: 95.0%

trimipramine N-oxide (14171-70-1) → trimipramine (739-71-9)

Guidance literature:

With sodium tetrahydroborate; In water; at 50 - 60 ℃; chemoselective reaction;

DOI:10.1016/j.tetlet.2010.08.045

upstream raw materials:

trimipramine

Downstream raw materials:

trimipramine

Refernces