Benzaldehyde, 2,5-difluoro-, oxime (9CI)

Base Information

• Chemical Name: Benzaldehyde, 2,5-difluoro-, oxime (9CI)
• CAS No.: 247092-13-3
• Molecular Formula: C7H5 F2 N O
• Molecular Weight: 157.12
• Mol file: 247092-13-3.mol

Synonyms:2,5-Difluorobenzaldehydeoxime

Chemical Property of Benzaldehyde, 2,5-difluoro-, oxime (9CI)

Chemical Property:

• Boiling Point: 207.0±30.0 °C(Predicted)
• PKA: 10.28±0.10(Predicted)
• PSA: 32.59000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 1.77290

Purity/Quality:

2,5-DIFLUOROBENZALDEHYDEOXIME 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde, 2,5-difluoro-, oxime (9CI)

There total 2 articles about Benzaldehyde, 2,5-difluoro-, oxime (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 2,5-difluorobenzaldehyde oxime (247092-13-3)

Guidance literature:

Reference yield: 95.0%

2,5-difluorobenzaldehyde (2646-90-4) → 2,5-difluorobenzaldehyde oxime (247092-13-3)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 4h; Solvent; Temperature;

Reference yield: 97.0%

4-morpholinocarbonyl chloride (15159-40-7) + 2,5-difluorobenzaldehyde oxime (247092-13-3) → (E)-2,5-di-fluorobenzaldehyde O-morpholine-4-carbonyloxime

Guidance literature:

4-morpholinocarbonyl chloride; 2,5-difluorobenzaldehyde oxime;

With triethylamine hydrochloride;

DOI:10.1016/j.bmcl.2006.08.031

upstream raw materials:

2,5-difluorobenzaldehyde

Downstream raw materials:

2,5-difluoro-N-hydroxybenzimidoyl chloride

5-(Chloro-difluoro-methyl)-3-(2,5-difluoro-phenyl)-isoxazole-4-carboxylic acid methyl ester

4-{(2,5-Difluoro-phenyl)-[(E)-hydroxyimino]-methyl}-piperazine-1-carboxylic acid tert-butyl ester

2,5-difluorobenzonitrile

Refernces

• 1、 -. "Triazole alcohol derivative as well as preparation method and application thereof". Paragraph 0199-0200. . Retrieved 2020/03/11.
• 2、 Xie, Fei,Ni, Tingjunhong,Zhao, Jing,Pang, Lei,Li, Ran,Cai, Zhan,Ding, Zichao,Wang, Ting,Yu, Shichong,Jin, Yongsheng,Zhang, Dazhi,Jiang, Yuanying. "Design, synthesis, and in vitro evaluation of novel antifungal triazoles". supporting information. p. 2171 - 2173. Retrieved 2017/04/28.