4-METHOXYBENZYL THIOACETIC ACID

Base Information

• Chemical Name: 4-METHOXYBENZYL THIOACETIC ACID
• CAS No.: 34722-37-7
• Molecular Formula: C10H12 O3 S
• Molecular Weight: 212.269
• Hs Code.: 2930909090
• Mol file: 34722-37-7.mol

Synonyms:Aceticacid, (p-methoxybenzylthio)- (6CI); Acetic acid,[[(4-methoxyphenyl)methyl]thio]- (9CI); ((4-Methoxybenzyl)sulfanyl)acetic acid;(p-Methoxybenzylthio)acetic acid; 2-(4-Methoxybenzylthio)acetic acid;S-(4-Methoxybenzyl)thioglycolic acid; [(4-Methoxybenzyl)thio]acetic acid;p-Methoxybenzylmercaptoacetic acid

Chemical Property of 4-METHOXYBENZYL THIOACETIC ACID

Chemical Property:

• Vapor Pressure: 4.97E-06mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 366.9°Cat760mmHg
• Flash Point: 175.7°C
• PSA: 71.83000
• Density: 1.238g/cm³
• LogP: 2.01300

Purity/Quality:

98%Min ^*data from raw suppliers

4-MethoxybenzylthioaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXYBENZYL THIOACETIC ACID

There total 8 articles about 4-METHOXYBENZYL THIOACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

p-Methoxybenzyl bromide (2746-25-0) + mercaptoacetic acid (68-11-1) → (4-methoxy-benzylsulfanyl)-acetic acid (34722-37-7)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1021/jm500258v

Reference yield: 84.0%

1-(carboethoxy)-1-(4-methoxybenzylthio)methane (65051-28-7) → (4-methoxy-benzylsulfanyl)-acetic acid (34722-37-7)

Guidance literature:

With sodium hydroxide; In methanol; for 1h; Ambient temperature;

DOI:10.1002/(SICI)1099-1344(199710)39:10<853::AID-JLCR31>3.0.CO;2-2

Reference yield: 80.0%

→ (4-methoxy-benzylsulfanyl)-acetic acid (34722-37-7)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 6h;

upstream raw materials:

1-(carboethoxy)-1-(4-methoxybenzylthio)methane

chloroacetic acid

p-methoxybenzyl chloride

4-Methoxybenzyl alcohol

Downstream raw materials:

2-(4-methoxybenzylmercapto)-acetohydroxamic acid

N,N'-bis((S-(4-methoxybenzyl)thio)acetamido)butanediamine-1,4

((4-methoxylbenzyl)sulfonyl)acetic acid

1-(4-fluorobenzyl)-3-(2-(4-methoxybenzylthio)acetyl)-2-methylisourea

Refernces

• 1、 Poras, Hervé,Patouret, Rémi,Leiris, Simon,Ouimet, Tanja,Fournié-Zaluski, Marie-Claude,Roques, Bernard P.. "Substituted α-mercaptoketones, new types of specific neprilysin inhibitors". . p. 3883 - 3890. Retrieved 2017/07/27.
• 2、 -. "MIXED INHIBITORS OF AMINOPEPTIDASE N AND NEPRILYSIN". Paragraph 0238-0241. . Retrieved 2015/11/18.