4-chloro-3, 5, dimethyl phenyl acetate

Base Information

• Chemical Name: 4-chloro-3, 5, dimethyl phenyl acetate
• CAS No.: 22012-58-4
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.649
• Mol file: 22012-58-4.mol

Synonyms:4-chloro-3, 5, dimethyl phenyl acetate

Chemical Property of 4-chloro-3, 5, dimethyl phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-3, 5, dimethyl phenyl acetate

There total 3 articles about 4-chloro-3, 5, dimethyl phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloro-3,5-dimethylphenol (88-04-0) + acetic anhydride (108-24-7) → 4-chloro-3, 5, dimethyl phenyl acetate (22012-58-4)

Guidance literature:

With sodium acetate;

Reference yield:

2,6-dimethyl-1-chlorobenzene (6781-98-2) + 2-(diacetoxyiodo)mesitylene (33035-41-5) → 3-chloro-2,4-dimethylphenyl acetate + 4-chloro-3, 5, dimethyl phenyl acetate (22012-58-4)

Guidance literature:

With acridine; palladium diacetate; In acetic anhydride; acetic acid; at 100 ℃; for 18h; Reagent/catalyst; Overall yield = 60 %; Overall yield = 133.4 mg;

DOI:10.1021/ol4024248

Reference yield:

[bis(acetoxy)iodo]benzene (3240-34-4) + 2,6-dimethyl-1-chlorobenzene (6781-98-2) → 3-chloro-2,4-dimethylphenyl acetate + 4-chloro-3, 5, dimethyl phenyl acetate (22012-58-4)

Guidance literature:

With palladium diacetate; In acetic anhydride; acetic acid; at 100 ℃; for 12h; Overall yield = 42 %Chromat.;

DOI:10.1021/ol4024248

upstream raw materials:

4-Chloro-3,5-dimethylphenol

acetic anhydride

2,6-dimethyl-1-chlorobenzene

2-(diacetoxyiodo)mesitylene

Refernces

• 1、 Cook, Amanda K.,Emmert, Marion H.,Sanford, Melanie S.. "Steric control of site selectivity in the Pd-catalyzed C-H acetoxylation of simple arenes". supporting information. p. 5428 - 5431. Retrieved 2013/11/19.