di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate

Base Information

• Chemical Name: di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate
• CAS No.: 97280-18-7
• Molecular Formula: C₃₁H₃₈N₆O₆
• Molecular Weight: 590.679
• Mol file: 97280-18-7.mol

Synonyms:di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate

Chemical Property of di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate

There total 2 articles about di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.8%

2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide (77766-62-2) + di-tert-butyl N-<4-<(cyanomethyl)amino>benzoyl>-L-glutamate (97280-17-6) → di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate (97280-18-7)

Guidance literature:

With 2,6-dimethylpyridine; In N,N-dimethyl acetamide; at 110 ℃; for 2.75h;

DOI:10.1021/jm00148a016

Reference yield:

di-tert-butyl (S)-N-(p-aminobenzoyl)-glutamate (76282-66-1) → di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate (97280-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / K₂CO₃, NaI / dimethylformamide / 1.75 h / 110 °C

2: 15.8 percent / 2,6-lutidine / N,N-dimethyl-acetamide / 2.75 h / 110 °C

With 2,6-dimethylpyridine; potassium carbonate; sodium iodide; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jm00148a016

Reference yield:

di-tert-butyl N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamate (97280-18-7) → N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamic acid (80015-09-4)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 25 ℃; for 2.75h;

DOI:10.1021/jm00148a016

upstream raw materials:

2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

di-tert-butyl N-<4-<(cyanomethyl)amino>benzoyl>-L-glutamate

di-tert-butyl (S)-N-(p-aminobenzoyl)-glutamate

Downstream raw materials:

N-<4--N-(cyanomethyl)amino>benzoyl>-L-glutamic acid

Refernces