4-METHOXYCINNAMOYL CHLORIDE

Base Information

• Chemical Name: 4-METHOXYCINNAMOYL CHLORIDE
• CAS No.: 34446-64-5
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.633
• Mol file: 34446-64-5.mol

Synonyms:p-Methoxycinnamoyl chloride;p-Methoxycinnamic acid chloride;p-Methoxycinnnamoyl chloride;4-Methoxycinnamic acid chloride;Cinnamoylchloride, p-methoxy- (7CI,8CI);

Chemical Property of 4-METHOXYCINNAMOYL CHLORIDE

Chemical Property:

• Melting Point: 49-50 °C
• Boiling Point: 317℃
• Flash Point: 118℃
• PSA: 26.30000
• Density: 1.207 g/cm³
• LogP: 2.47380

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-METHOXYCINNAMOYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-METHOXYCINNAMOYL CHLORIDE

There total 21 articles about 4-METHOXYCINNAMOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) → (E)-3-(4-methoxyphenyl)propenoyl chloride (34446-64-5,42996-84-9)

Guidance literature:

With oxalyl dichloride;

DOI:10.1016/S0040-4020(00)00088-0

Reference yield: 98.0%

3-(4'-methoxyphenyl)propenoic acid (830-09-1) → p-methoxycinnamoyl chloride (42996-84-9,34446-64-5)

Guidance literature:

With thionyl chloride; In 1,2-dichloro-ethane; for 3h; Heating;

Reference yield: 95.0%

oxalyl dichloride (79-37-8) + (E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) → (E)-3-(4-methoxyphenyl)propenoyl chloride (34446-64-5,42996-84-9)

Guidance literature:

In toluene; for 20h; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2270::AID-HLCA2270>3.0.CO;2-#

upstream raw materials:

3-(4'-methoxyphenyl)propenoic acid

4-hydroxy-benzaldehyde

4-methoxy-benzaldehyde

para-coumaric acid

Downstream raw materials:

2'-hydroxy-4,3',4',5',6'-pentamethoxy-trans-chalcone

4-chloro-17β-(4-methoxy-trans-cinnamoyloxy)-androst-4-en-3-one

3-(4-methoxyphenyl)-N-(4-methoxyphenyl)prop-(2E)-enamide

methyl p-methoxycinnamate

Refernces

• 1、 Liu, Yue,Li, Peng-Xiao,Mu, Wen-Wen,Sun, Ya-Lei,Liu, Ren-Min,Yang, Jie,Liu, Guo-Yun. "Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives". . . Retrieved 2022/01/13.
• 2、 Malbari, Khushboo,Saha, Priyanka,Chawla-Sarkar, Mamta,Dutta, Shanta,Rai, Swita,Joshi, Mamata,Kanyalkar, Meena. "In quest of small-molecules as potent non-competitive inhibitors against influenza". . . Retrieved 2021/07/19.