6-Methoxy-N-ethylquinolinium iodide

Base Information

• Chemical Name: 6-Methoxy-N-ethylquinolinium iodide
• CAS No.: 34373-76-7
• Molecular Formula: C12H14NO^.I
• Molecular Weight: 315.154
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID70385119
• ChEMBL ID: CHEMBL592308
• Mol file: 34373-76-7.mol

Synonyms:34373-76-7;6-METHOXY-N-ETHYLQUINOLINIUM IODIDE;1-ethyl-6-methoxyquinolin-1-ium iodide;MEQ;1-ethyl-6-methoxyquinolin-1-ium;iodide;6-METHOXY-N-ETHYLQUINOLINIUMIODIDE;1-ethyl-6-methoxyquinolinium iodide;SCHEMBL222931;CHEMBL592308;DTXSID70385119;AKOS000814306;HY-W247130;AS-62505;CS-0373892;SJ000140393;D96040;A924606;J-019571

Chemical Property of 6-Methoxy-N-ethylquinolinium iodide

Chemical Property:

• Melting Point: 182–183 ℃
• PSA: 13.11000
• LogP: -0.84020
• Solubility.: Soluble in water, dimethyl sulfoxide
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 315.01201
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

MEQ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC[N+]1=CC=CC2=C1C=CC(=C2)OC.[I-]
• Uses: MEQ is a cell membrane impermeable chloride indicator..

Technology Process of 6-Methoxy-N-ethylquinolinium iodide

There total 1 articles about 6-Methoxy-N-ethylquinolinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

6-methoxy quinoline (5263-87-6) + ethyl iodide (75-03-6) → 1-ethyl-6-methoxyquinolin-1-ium iodide (34373-76-7)

Guidance literature:

In toluene; Heating;

DOI:10.1002/jhet.5570240334

Reference yield: 65.0%

1-ethyl-6-methoxyquinolin-1-ium iodide (34373-76-7) + phenylboronic acid (98-80-6) → (S)-1-ethyl-6-methoxy-2-phenyl-1,2-dihydroquinoline

Guidance literature:

With (S)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(diphenylphosphine); silver tetrafluoroborate; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; potassium phosphate tribasic trihydrate; In tetrahydrofuran; at 45 ℃; for 12h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201511663

Reference yield:

1-ethyl-6-methoxyquinolin-1-ium iodide (34373-76-7) → 1-ethyl-6-methoxy-1H-quinolin-2-one (63816-12-6)

Guidance literature:

With alkaline potassium ferricyanide;

upstream raw materials:

6-methoxy quinoline

ethyl iodide

Downstream raw materials:

1-ethyl-6-methoxy-1H-quinolin-2-one

1-ethyl-6-methoxy-2-(4-methoxy-phenyl)-1,2-dihydro-quinoline

Refernces

• 1、 Sun, Xingxing,Zhang, Baicheng,Li, Xinyang,Trindle, Carl O.,Zhang, Guoqing. "External Heavy-Atom Effect via Orbital Interactions Revealed by Single-Crystal X-ray Diffraction". . p. 5791 - 5797. Retrieved 2016/08/05.