Technology Process of methyl 2-phenyl-1-(thiophene-2-carbonyl)cyclopropanecarboxylate
There total 3 articles about methyl 2-phenyl-1-(thiophene-2-carbonyl)cyclopropanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
styrene;
With
bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]};
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
Inert atmosphere;
methyl 2-diazo-3-oxo-3-(thiophen-2-yl)propanoate;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol200305n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 4-toluenesulfonyl azide; triethylamine / acetonitrile / 3.08 h / Inert atmosphere
2.1: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / dichloromethane / 0.08 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
4-toluenesulfonyl azide; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; triethylamine;
In
dichloromethane; acetonitrile;
DOI:10.1021/ol200305n
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C
2.1: 4-toluenesulfonyl azide; triethylamine / acetonitrile / 3.08 h / Inert atmosphere
3.1: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / dichloromethane / 0.08 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
4-toluenesulfonyl azide; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol200305n