1-Methylpiperazine dihydrochloride

Base Information

• Chemical Name: 1-Methylpiperazine dihydrochloride
• CAS No.: 34352-59-5
• Molecular Formula: C₅H₁₄N₂*2Cl
• Molecular Weight: 173.086
• Hs Code.: 2933599090
• European Community (EC) Number: 628-185-9
• DSSTox Substance ID: DTXSID30370460
• Mol file: 34352-59-5.mol

Synonyms:1-methylpiperazine;1-methylpiperazine dihydrochloride;1-methylpiperazine hydrochloride;1-methylpiperazine monohydrochloride

Chemical Property of 1-Methylpiperazine dihydrochloride

Chemical Property:

• Appearance/Colour: off-white to light yellow powder
• Vapor Pressure: 6.86mmHg at 25°C
• Melting Point: 246-250 °C(lit.)
• Boiling Point: 138 °C at 760 mmHg
• Flash Point: 42.2 °C
• PSA: 15.27000
• LogP: 1.39210
• Storage Temp.: Refrigerator
• Solubility.: 1 M NH4OH: soluble25mg/mL, clear to hazy, colorless to light yel
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.0534038
• Heavy Atom Count: 9
• Complexity: 48

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methylpiperazine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCNCC1.Cl.Cl
• Uses: 1-Methylpiperazine dihydrochloride is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP). 1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug. 1-Methylpiperazine dihydrochloride (Methylpiperazine dihydrochloride) has been used in the preparation of 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate.

Technology Process of 1-Methylpiperazine dihydrochloride

There total 11 articles about 1-Methylpiperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzyl-4-methylpiperazine (62226-74-8) → 1-methylpiperazine hydrochloride (34352-59-5,50398-09-9,51545-09-6)

Guidance literature:

With 1,1,2-trichloroethane; 10% palladium on activated carbon; hydrogen; In methanol; for 1h; under 760.051 Torr; chemoselective reaction;

DOI:10.1021/jo9007282

Reference yield: 56.0%

1-methyl-4-(2-tetrahydropyrimidinylthioacetyl)piperazine dihydrochloride (93378-52-0) → 2H,5H,-6,7-dihydrothiazolo<3,2-a>pyrimidin-3(2H)-one (92897-32-0) + N-methylpiperazine dihydrochloride (50398-09-9,51545-09-6,34352-59-5)

Guidance literature:

In ethanol; for 0.0833333h; Product distribution; Heating;

DOI:10.1007/BF00508682

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) → N-methylpiperazine dihydrochloride (50398-09-9,51545-09-6,34352-59-5)

Guidance literature:

1-methylpiperazin-2,5-dione; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h; Heating / reflux;

hydrogenchloride; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

3,4,5,6-tetrahydropyrimidine-2-thione

2-chloro-1-(4-methylpiperazin-1-yl)ethan-1-one hydrochloride

1-methyl-4-(2-tetrahydropyrimidinylthioacetyl)piperazine dihydrochloride

1-methyl-4-(2-tetrahydro-1,3-diazepinylthioacetyl)piperazine dihydrochloride

Downstream raw materials:

3-(4-methylpiperazin-1-yl)-1-phenylpropan-1-one

1-(2-ethoxy-2-oxoethyl)-4-methylpiperazine

1-(4-methoxy-phenyl)-3-(4-methyl-piperazin-1-yl)-propan-1-one

levofloxacin

Refernces

• 1、 -. "7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE". Page/Page column 37-38; 116-117; 140-141. . Retrieved 2008/12/08.
• 2、 -. "Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof". Page/Page column 11. . Retrieved 2008/06/13.