2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide

Base Information

• Chemical Name: 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide
• CAS No.: 1030624-36-2
• Molecular Formula: C₁₁H₁₄ClNO₂
• Molecular Weight: 227.691
• Mol file: 1030624-36-2.mol

Synonyms:2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide

Chemical Property of 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide

Chemical Property:

• Boiling Point: 443.1±35.0 °C(Predicted)
• Density: 1.214±0.06 g/cm3(Predicted)

Purity/Quality:

≥99% ^*data from raw suppliers

4-Chloro-N-(2-hydroxypropyl)benzeneacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-N-(2-hydroxypropyl)benzeneacetamide is used as a reagent in the synthesis of Lorcaserin Hydrochloride (L469890); a novel selective 5-HT2C-receptor agonist for the treatment of obesity.

Technology Process of 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide

There total 3 articles about 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chlorophenylacetic Acid (1878-66-6) + 3-amino-2-propanol (78-96-6,1674-56-2) → 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide (1030624-36-2)

Guidance literature:

With boric acid; In toluene; at 40 - 135 ℃; for 24h; Time;

Reference yield:

4-chlorophenylacetic Acid (1878-66-6) + 3-amino-2-propanol (78-96-6,1674-56-2) → 2-(4-chlorobenzyl)-5-methyl-4,5-dihydrooxazole (1030624-39-5) + 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide (1030624-36-2)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In isopropyl alcohol; at 20 ℃; for 16h; Product distribution / selectivity;

Reference yield:

(4-chloro-phenyl)-acetic acid methyl ester (52449-43-1) + 3-amino-2-propanol (78-96-6,1674-56-2) → 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide (1030624-36-2)

Guidance literature:

In methanol; at 90 ℃; for 12h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

4-chlorophenylacetic Acid

3-amino-2-propanol

(4-chloro-phenyl)-acetic acid methyl ester

Downstream raw materials:

1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane

1-((4-chlorophenethyl)amino)propan-2-ol hydrochloride

1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride

2-chloro-N-(4-chlorophenethyl)propanamine

Refernces

• 1、 -. "A preparing method of (R,S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a lorcaserin intermediate". Paragraph 0051; 0052. . Retrieved 2016/10/17.
• 2、 -. "PROCESSES FOR PREPARING (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES THEREOF". Page/Page column 18. . Retrieved 2008/12/06.