Technology Process of 9-(1-methyl-1H-imidazol-2-yl)-8-(4-(pyrrolidin-1-ylmethyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
There total 11 articles about 9-(1-methyl-1H-imidazol-2-yl)-8-(4-(pyrrolidin-1-ylmethyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
pyrrolidine; 4-(9-(1-methyl-1H-imidazol-2-yl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde;
With
acetic acid;
In
acetonitrile;
at 20 ℃;
for 4h;
With
sodium cyanoborohydride;
In
acetonitrile;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: nitric acid / sulfuric acid / 3.5 h / -5 - 0 °C
2.1: thionyl chloride / methanol / 16 h / 0 °C / Reflux
3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux
4.1: 1,4-dioxane; water / 96 h / Reflux
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr
6.1: magnesium sulfate / dichloromethane / Reflux
7.1: ethanol / 3 h / 20 °C
8.1: hydrazine hydrate / methanol / 3 h / 25 °C
9.1: hydrogenchloride / water / 2 h / 20 °C
9.2: pH 7
10.1: acetic acid / dichloromethane / 4 h / 20 °C
10.2: 4 h / 0 °C
With
hydrogenchloride; N-Bromosuccinimide; thionyl chloride; hydrogen; nitric acid; magnesium sulfate; hydrazine hydrate; acetic acid; dibenzoyl peroxide;
sulfuric acid; palladium 10% on activated carbon;
In
1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux
2.1: 1,4-dioxane; water / 96 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr
4.1: magnesium sulfate / dichloromethane / Reflux
5.1: ethanol / 3 h / 20 °C
6.1: hydrazine hydrate / methanol / 3 h / 25 °C
7.1: hydrogenchloride / water / 2 h / 20 °C
7.2: pH 7
8.1: acetic acid / dichloromethane / 4 h / 20 °C
8.2: 4 h / 0 °C
With
hydrogenchloride; N-Bromosuccinimide; hydrogen; magnesium sulfate; hydrazine hydrate; acetic acid; dibenzoyl peroxide;
palladium 10% on activated carbon;
In
1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate;