7-CHLORO-5-PHENYL-2-THIOXO-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE

Base Information

• Chemical Name: 7-CHLORO-5-PHENYL-2-THIOXO-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE
• CAS No.: 34099-69-9
• Molecular Formula: C15H12 N2 S
• Molecular Weight: 252.34
• Hs Code.: 2933990090
• Mol file: 34099-69-9.mol

Synonyms:7-CHLORO-5-PHENYL-2-THIOXO-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE

Chemical Property of 7-CHLORO-5-PHENYL-2-THIOXO-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE

Chemical Property:

• Melting Point: 236-238 °C
• Boiling Point: 379.8±52.0 °C(Predicted)
• PKA: 10.06±0.40(Predicted)
• PSA: 56.48000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 3.50390

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-5-PHENYL-2-THIOXO-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE

There total 3 articles about 7-CHLORO-5-PHENYL-2-THIOXO-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (2898-08-0) → 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione (34099-69-9)

Guidance literature:

With n-butyllithium; tetraphosphorus decasulfide; In tetrahydrofuran; hexane; for 16h; Heating;

DOI:10.1055/s-1987-27871

Reference yield:

→ 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione (34099-69-9)

Guidance literature:

5-Phenyl-1.3-dihydro-2H-1.4-benzodiazepinon-(2), P2S5, w.-freies Pyridin, Siedetemp., 3/4 h;

DOI:10.1021/jo01024a511

Reference yield:

→ N2-acetyl-N5-hydroxy-N5-(5-hydroxy-3-methyl-pent-2-enoyl)-ornithine 4-{[hydroxy-(5-{3-[hydroxy-(5-hydroxy-3-methyl-pent-2-enoyl)-amino]-propyl}-3,6-dioxo-piperazin-2-yl)-propyl]-carbamoyl}-3-methyl-but-2-enyl ester (30315-65-2)

Guidance literature:

Coprogen, 8-Hydroxy-chinolin/wss. MeOH;

DOI:10.1002/hlca.19700530813

upstream raw materials:

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

Downstream raw materials:

2-[1-Methyl-2-(6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulen-1-yl)-ethyl]-isoindole-1,3-dione

dimethyl-(6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine

2-(6-Phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulen-1-yl)-ethylamine

C₁₇H₁₄N₂S

Refernces

• 1、 Del Pozo, Carlos,Macias, Alberto,Alonso, Eduardo,Gonzalez, Javier. "Reactions of 1,4-benzodiazepinic N-nitrosoamidines with tosylmethyl isocyanide: A novel synthesis of midazolam". . p. 2697 - 2703. Retrieved 2007/10/03.
• 2、 Goel, O. P.,Krolls, U.. "Reaction of Phosphorus Pentasulfide with Organolithiums. An In Situ Reagent for the Preparation of Thiolactams". . p. 162 - 164. Retrieved 2007/10/02.