5-(4-Methylphenyl)-2-furaldehyde

Base Information

• Chemical Name: 5-(4-Methylphenyl)-2-furaldehyde
• CAS No.: 34035-05-7
• Molecular Formula: C12H10 O2
• Molecular Weight: 186.21
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID90359337
• Nikkaji Number: J1.627.334A
• Wikidata: Q82140511
• Mol file: 34035-05-7.mol

Synonyms:5-(4-methylphenyl)-2-furaldehyde;34035-05-7;5-(4-methylphenyl)furan-2-carbaldehyde;5-(p-Tolyl)furan-2-carbaldehyde;5-(p-Tolyl)furfural;SCHEMBL2318474;5-p-Tolyl-furan-2-carbaldehyde;DTXSID90359337;RNXBPIBAPRFYIS-UHFFFAOYSA-N;MFCD04084770;STL255926;AKOS000113015;NCGC00333594-01;5-(4-methyl phenyl)furan-2-carbaldehyde;2-furancarboxaldehyde, 5-(4-methylphenyl);BB 0222880;CS-0116728;FT-0706605;EN300-25497;F77552;AB01127267-03;Z57243662

Chemical Property of 5-(4-Methylphenyl)-2-furaldehyde

Chemical Property:

• Vapor Pressure: 0.000148mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 332.2°Cat760mmHg
• Flash Point: 107.5°C
• PSA: 30.21000
• Density: 1.125g/cm³
• LogP: 3.06750
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 186.068079557
• Heavy Atom Count: 14
• Complexity: 195

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-(4-methylphenyl)furan-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CC=C(O2)C=O

Technology Process of 5-(4-Methylphenyl)-2-furaldehyde

There total 16 articles about 5-(4-Methylphenyl)-2-furaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + 4-methylphenylboronic acid (5720-05-8) → 5-(4-tolyl)-2-furaldehyde (34035-05-7)

Guidance literature:

5-bromo-2-furancarboxaldehyde; With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-methylphenylboronic acid; In 1,2-dimethoxyethane; water; at 90 ℃; Inert atmosphere;

DOI:10.2298/JSC170213033A

Reference yield: 91.0%

5-formylfurane-2-boronic acid (27329-70-0) + para-bromotoluene (106-38-7) → 5-(4-tolyl)-2-furaldehyde (34035-05-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In methanol; at 120 ℃; for 2h; under 0 Torr;

DOI:10.1039/c4ob01641f

Reference yield: 90.0%

4-tolyl iodide (624-31-7) + 5-tri-n-butylstannyl-2-furannecarbaldehyde → 5-(4-tolyl)-2-furaldehyde (34035-05-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 50 ℃; for 2h;

DOI:10.1016/S0968-0896(02)00600-4

upstream raw materials:

furfural

p-methylbenzenediazonium chloride

p-toluidine

4-tolyl iodide

Downstream raw materials:

2-thioxo-5-(5-p-tolyl-furan-2-ylmethylene)-thiazolidin-4-one

5-(p-Methylphenyl)-2-furamidoxime

5-[5-(4-methyl-phenyl)-furan-2-ylmethylene]thiazolidine-2,4-dione

5-[5-(4-methyl-phenyl)furan-2-ylmethylene]-2-thioxo-dihydropyrimidine-4,6-dione

Refernces

• 1、 Niu, Tianwei,Wang, Peipei,Li, Cheng,Dou, Tong,Piao, Huri,Li, Jia,Sun, Liangpeng. "5-Aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety as potential PTP1B inhibitors". . . Retrieved 2020/12/04.
• 2、 Yang, Yongjie,Fei, ChengCheng,Wang, Kai,Liu, Bo,Jiang, Dingxin,Yin, Biaolin. "Access to Densely Functionalized Chalcone Derivatives with a 2-Pyridone Subunit via Pd/Cu-Catalyzed Oxidative Furan-Yne Cyclization of N -(2-Furanylmethyl) Alkynamides under Air". supporting information. p. 2273 - 2277. Retrieved 2018/04/30.