1-(2-bromophenyl)-2-iodoethanone

Base Information

• Chemical Name: 1-(2-bromophenyl)-2-iodoethanone
• CAS No.: 1345692-78-5
• Molecular Formula: C₈H₆BrIO
• Molecular Weight: 324.944
• Mol file: 1345692-78-5.mol

Synonyms:1-(2-bromophenyl)-2-iodoethanone

Chemical Property of 1-(2-bromophenyl)-2-iodoethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-bromophenyl)-2-iodoethanone

There total 3 articles about 1-(2-bromophenyl)-2-iodoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromophenyl methyl ketone (2142-69-0) → 1-(2-bromophenyl)-2-iodoethanone (1345692-78-5)

Guidance literature:

With ammonium iodide; Oxone; In methanol; for 8h; Reflux;

DOI:10.1016/j.tetlet.2011.09.106

Reference yield: 79.0%

2-bromostyrene (2039-88-5) → 1-(2-bromophenyl)-2-iodoethanone (1345692-78-5)

Guidance literature:

With iodoform; [bis(acetoxy)iodo]benzene; In 1,4-dioxane; at 20 ℃; Irradiation;

DOI:10.1016/j.cclet.2020.02.022

Reference yield:

2-bromo-1-ethynylbenzene (766-46-1) → 1-(2-bromophenyl)-2-iodoethanone (1345692-78-5)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In water; at 120 ℃; for 1h; Sealed tube;

DOI:10.1039/c4ra07556k

upstream raw materials:

2-bromophenyl methyl ketone

2-bromostyrene

2-bromo-1-ethynylbenzene

Refernces

• 1、 Kalmode, Hanuman P.,Vadagaonkar, Kamlesh S.,Chaskar, Atul C.. "Metal-free in situ sp3, sp2, and sp C-H functionalization and oxidative cross coupling with benzamidines hydrochloride: A promising approach for the synthesis of α-ketoimides". . p. 60316 - 60326. Retrieved 2015/02/19.