TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
• CAS No.: 239066-69-4
• Molecular Formula: C10H20 N2 O3
• Molecular Weight: 216.28
• Mol file: 239066-69-4.mol

Synonyms:BUTTPARK 46\04-31;BOC-N-(2-HYDROXYETHYL)PIPERAZINE;4-(2-HYDROXYETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(2-HYDROXYETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;4-(HYDROXYMETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;1-BOC-4-(2-HYDROXYETHYL)-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)-4-(2-HYDROXYETHYL)PIPERAZINE;TERT-BUTYL 4-(2-HYDROXYETHYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

Chemical Property of TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.000101mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 301.7°Cat760mmHg
• PKA: 14.59±0.10(Predicted)
• Flash Point: 136.3°C
• PSA: 53.01000
• Density: 1.112g/cm³
• LogP: 0.36470

Purity/Quality:

98% ^*data from raw suppliers

1-Piperazinecarboxylic acid, 4-(hydroxymethyl)-, 1,1-dimethylethyl ester 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE

There total 1 articles about TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(hydroxymethyl)piperazine-1-carboxylate (239066-69-4)

Guidance literature:

1-t-Butoxycarbonylpiperazine; With acetic acid; In water; at 25 ℃; for 0.666667h;

formaldehyd; In water; at 25 - 30 ℃; for 1.5h;

Reference yield: 64.0%

tert-butyl 4-(hydroxymethyl)piperazine-1-carboxylate (239066-69-4) + benzyl N-[(1S)-1-(4-hydroxyphenyl)ethyl]carbamate (645391-89-5) → tert-butyl 3-[[4-[(1S)-1-(benzyloxycarbonylamino)ethyl]phenoxy]methyl]azetidine-1-carboxylate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 4.75h;

Reference yield: 46.0%

tert-butyl 4-(hydroxymethyl)piperazine-1-carboxylate (239066-69-4) + 7-[[(1S)-1-(4-bromophenyl)ethyl]amino]-1-isopropyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one → tert-butyl 4-[4-[(1S)-1-[(1-isopropyl-2-oxo-4H-pyrimido[4,5-d][1,3]oxazin-7-yl)amino]ethyl]phenyl]piperazine-1-carboxylate

Guidance literature:

With potassium carbonate; copper(I) bromide; hydroxy L-proline; In dimethyl sulfoxide; at 80 ℃;

upstream raw materials:

formaldehyd

1-t-Butoxycarbonylpiperazine

Refernces