Benzothiazole, 4-methoxy- (7CI,8CI,9CI)

Base Information

• Chemical Name: Benzothiazole, 4-methoxy- (7CI,8CI,9CI)
• CAS No.: 3048-46-2
• Molecular Formula: C8H7NOS
• Molecular Weight: 165.216
• Hs Code.: 29342000
• Mol file: 3048-46-2.mol

Synonyms:4-Methoxybenzothiazole;

Chemical Property of Benzothiazole, 4-methoxy- (7CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Melting Point: 103 °C
• Refractive Index: 1.646
• Boiling Point: 274.42 °C at 760 mmHg
• PKA: 1.00±0.10(Predicted)
• Flash Point: 119.765 °C
• PSA: 50.36000
• Density: 1.268 g/cm³
• LogP: 2.30490
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Methoxy-benzothiazole 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzothiazole, 4-methoxy- (7CI,8CI,9CI)

There total 8 articles about Benzothiazole, 4-methoxy- (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methoxy-1,3-benzothiazol-2-amine (5464-79-9) → 4-methoxybenzo[d]thiazole (3048-46-2)

Guidance literature:

With isopentyl nitrite; In 1,4-dioxane; at 20 ℃; for 0.333333h;

DOI:10.1016/j.bmcl.2010.08.112

Reference yield: 33.0%

carbon dioxide (124-38-9,18923-20-1) + 2-amino-3-methoxybenzenethiol (73931-64-3) → 4-methoxybenzo[d]thiazole (3048-46-2)

Guidance literature:

carbon dioxide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 0.5h; under 760.051 Torr; Schlenk technique;

2-amino-3-methoxybenzenethiol; With phenylsilane; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 24h; under 760.051 Torr; Schlenk technique;

DOI:10.1016/j.tet.2017.05.003

Reference yield:

N-(4-methoxybenzo[d]thiazol-2-yl)acetamide (90915-52-9) → 4-methoxybenzo[d]thiazole (3048-46-2)

Guidance literature:

With water; hypophosphorous acid; sodium nitrite; at -15 - 20 ℃;

DOI:10.1016/j.bmcl.2008.09.042

upstream raw materials:

4-methoxybenzo[d]thiazole-2-carboxylic acid

4-methoxy-1,3-benzothiazol-2-amine

N-(4-methoxybenzo[d]thiazol-2-yl)acetamide

2-methoxy-phenylamine

Downstream raw materials:

4-hydroxybenzothiazole

4-Oxiranylmethoxy-benzothiazole

2-amino-3-methoxybenzenethiol

2-(phenylthio)-4-methoxybenzo[d]thiazole

Refernces

• 1、 -. "COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF". Paragraph 0380. . Retrieved 2016/10/27.
• 2、 -. "NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION". Page/Page column 183. . Retrieved 2011/07/06.