4-(TRIFLUOROMETHYL)BENZYLAMINE

Base Information

• Chemical Name: 4-(TRIFLUOROMETHYL)BENZYLAMINE
• CAS No.: 3047-99-2
• Molecular Formula: C8H8 F3 N . Cl H
• Molecular Weight: 211.614
• Hs Code.: 2921499090
• Mol file: 3047-99-2.mol

Synonyms:Benzenemethanamine,4-(trifluoromethyl)-, hydrochloride (9CI); Benzylamine, p-(trifluoromethyl)-,hydrochloride (7CI,8CI); 4-trifluoromethylbenzylamine hydrochloride;p-Trifluoromethylbenzylamine hydrochloride

Chemical Property of 4-(TRIFLUOROMETHYL)BENZYLAMINE

Chemical Property:

• Melting Point: 194-198 °C
• Boiling Point: 191°Cat760mmHg
• Flash Point: 75°C
• PSA: 26.02000
• Density: 1.225g/cm³
• LogP: 2.86440
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%min ^*data from raw suppliers

4-(Trifluoromethyl)benzylamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TRIFLUOROMETHYL)BENZYLAMINE

There total 14 articles about 4-(TRIFLUOROMETHYL)BENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-CF3C6H4CN (455-18-5) → 4-trifluoromethylbenzylamine hydrochloride (3047-99-2)

Guidance literature:

With hydrogenchloride; hydrogen; In 1,4-dioxane; methanol; at 60 ℃; for 18h; under 375.038 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield: 91.0%

4,4,5,5-tetramethyl-N-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)-benzyl)-1,3,2-dioxaborolan-2-amine → 4-trifluoromethylbenzylamine hydrochloride (3047-99-2)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.1c00106

Reference yield: 86.0%

p-Trifluoromethylbenzylamine (3300-51-4) → 4-trifluoromethylbenzylamine hydrochloride (3047-99-2)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1039/c7cy01577a

upstream raw materials:

4-CF₃C₆H₄CN

2-[(4-trifluoromethyl)phenyl]acetamide

4-Trifluoromethylbenzaldehyde

4-(trifluoromethyl)benzaldehyde oxime

Downstream raw materials:

(3R,4S)-tert-butyl 4-((4-(1-allyl-3-(4-(trifluoromethyl)benzyl)ureido)piperidin-1-yl)methyl)-3-hydroxy-3-phenylpyrrolidine-1-carboxylate

2,6-dichloro-N-(4-trifluoromethylbenzyl)benzamide

Refernces

• 1、 Bhattacharjee, Jayeeta,Bockfeld, Dirk,Tamm, Matthias. "N-Heterocyclic Carbene-Phosphinidenide Complexes as Hydroboration Catalysts". supporting information. p. 1098 - 1109. Retrieved 2022/01/27.
• 2、 -. "Method for preparing amine compound by reducing amide compound". Paragraph 0217-0219. . Retrieved 2021/02/10.