2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 236406-39-6
• Molecular Formula: C13H24N2O2
• Molecular Weight: 240.346
• Hs Code.: 29339900
• Mol file: 236406-39-6.mol

Synonyms:tert-Butyl2,8-diazaspiro[4.5]decane-8-carboxylate;

Chemical Property of 2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 337.028 °C at 760 mmHg
• PKA: 11.04±0.20(Predicted)
• Flash Point: 157.629 °C
• PSA: 41.57000
• Density: 1.073 g/cm³
• LogP: 2.26370
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,8-Diazaspiro[4.5]decane-8-carboxylicacidtert-butylester 97.0% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 2,8-Diazaspiro[4.5]decane-8-carboxylate is used in preparation of substituted aminoquinolones as DGKα inhibitors for immune activation.

Technology Process of 2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 10 articles about 2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.98%

C13H21ClN2O2 → 2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (236406-39-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield: 67.0%

tert-butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate (236406-40-9) → 2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (236406-39-6)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; at 20 ℃; for 1h; Reflux; Inert atmosphere;

Reference yield:

C13H24N2O3 → 2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (236406-39-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

upstream raw materials:

1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate

tert-butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate

Downstream raw materials:

tert-butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate

tert-butyl 2-[4-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

tert-butyl 2-{3-[2-({[4-(2-methoxy-2-oxoethyl)benzyl][(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]amino}methyl)-1H-imidazol-1-yl]propyl}-2,8-diazaspiro[4.5]decane-8-carboxylate

Refernces

• 1、 -. "2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD)". Page/Page column 94. . Retrieved 2016/04/09.
• 2、 -. "NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES". Page/Page column 86; 87-88. . Retrieved 2008/06/13.